Polyphenol modified liposome nano system as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of medical health and biomedical materials, and particularly relates to a polyphenol modified lipidosome nano system. The polyphenol modified lipidosome nano system comprises lipidosome, polyphenol, an oxidizing agent, a buffer solution serving as a reaction solvent and a hydrothermal reaction kettle with a polytetrafluoroethylene lining. The preparation method comprises the following steps of preparing lipidosome by adopting a film drying method, and preparing the polyphenol modified lipidosome nano system by adopting a one-pot hydrothermal method; and the lipidosome is more easily permeated into the cuticle of the skin and can be well distributed, degradation and deterioration of many active substances can be prevented due to the wrapping effect of lipidosome, and polyphenol has rich and complex physical and chemical properties and has wide chemical purposes including ultraviolet absorption, free radical removal and metal ion complexation. The system is also commonly used for promoting delivery of protein, nucleic acid and conventional drug molecules, so that the system can be used as a universal platform for delivering protein, nucleic acid, conventional drug molecules and the like; and the preparation method is simple and convenient, short in reaction time, low in cost, environment-friendly and safe.

Description

technical field [0001] The invention belongs to the technical field of medical health and biomedical materials, and specifically relates to a polyphenol-modified liposome nanosystem, a preparation method and application of a polyphenol-modified liposome nanosystem, and a polyphenol-modified liposome nanosystem. Applications of Liposome Nanosystems. Background technique [0002] Phenols and polyphenols are widely distributed in plant tissues, and they are involved in various biological functions, such as chemical defense, pigmentation, structural support and protection against radiation damage, and members of this large family include epigallocatechin gallate (EGCG), epigallocatechin gallate (ECG), epigallocatechin (EGC) and tannic acid (TA), plant polyphenols have rich and complex physical and chemical properties, and have a wide range of chemical uses , including absorbing ultraviolet rays, scavenging free radicals, and complexing metal ions, so polyphenols are also common...

AI Technical Summary

Problems solved by technology

[0003] Liposome has developed rapidly as a new type of drug carrier in the field of medicine. Liposome is a bimolecular vesicle composed of phospholipid molecules. As a drug carrier, liposome has many advantages: It can encapsulate fat-soluble drugs and water-soluble drugs. It can effectively protect the encapsulated drugs, improve bioavailability, make the drugs have eight functions, and reduce the toxic and side effects of drugs. Liposomes have the function of slow and controlled release. , suitable for multi-way drug delivery, etc. Due to its unique structural characteristics, liposomes, as a new type of drug carrier, have brought pharmaceutical preparations into the new world of targeted drug delivery, and have received increasingly widespread attention in the medical field. Liposomes are mainly It is a bilayer microvesicle formed by phospholipids and cholesterol or other additives similar to the structure of a biological membrane. It is non-toxic, non-immunogenic, and has a good loading capacity for water-soluble and fat-soluble drugs. It has been widely Applied in the field of drug delivery, it improves the stability of the drug, prolongs its action time, and reduces its irritation, making it easier to pass through the pores of the skin and accelerate skin absorption, but its own stability is also relatively weakened, which affects the long-term effect of growth factors. Effectiveness

[0004] For polyphenols and liposomes, the current commonly used method is to use liposomes to carry polyphenols, but the traditional method is complicated, the reaction time is long, the cost is high, and it is difficult to ensure safety.

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