Novel nano tranexamic acid targeting preparation and preparation method thereof

A tranexamic acid, targeting technology, applied in the field of biochemistry, can solve the problems of difficult to penetrate into the bottom layer of the skin, stay in the stratum corneum, small emulsion particle size, etc., achieve small emulsion particle size, fast targeting speed, improve effect of effect

Pending Publication Date: 2021-11-19
杭州拾珍医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems of long action period of tranexamic acid products in the above prior art, useful substances can only stay in the stratum corneum, and it is difficult to penetrate into the bottom layer of the skin, etc., the present invention provides a tranexamic acid with short service period and fast targeting action speed , and the raw materials have a more comfortable skin feel, smaller emulsified particle size, and a new nano-tranexamic acid targeted preparation and a preparation method thereof that make the final nano-preparation targeting effect more obvious

Method used

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  • Novel nano tranexamic acid targeting preparation and preparation method thereof
  • Novel nano tranexamic acid targeting preparation and preparation method thereof
  • Novel nano tranexamic acid targeting preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A novel nanometer tranexamic acid targeting preparation, its raw material percentage by weight is as follows:

[0032]

[0033] The preparation method of the above-mentioned novel nanometer tranexamic acid targeting preparation, the steps are as follows:

[0034] (1) Weigh squalane, caprylic / capric triglyceride, hydrogenated lecithin and heat to 60-80°C

[0035] Obtain the oil phase; weigh deionized water, tranexamic acid, and hyaluronic acid and heat to 60-80°C

[0036] get the aqueous phase;

[0037] (2) Mix the oil phase and the water phase, and homogenize in a vacuum homogenizer for 5-15min at a speed of 1000-2000rpm;

[0038] (3) After vacuum homogenization, start stirring and cool down to 40°C, add papain, vitamin E, and phenoxyethanol, and continue stirring to obtain colostrum;

[0039] (4) The colostrum is transferred to a high-pressure homogenizer and circulated for 5-15 weeks at a pressure of 500-1500 bar to obtain liquid essence milk.

Embodiment 2

[0041] A novel nanometer tranexamic acid targeting preparation, its raw material percentage by weight is as follows:

[0042]

[0043]

[0044] The preparation method of the above-mentioned novel nanometer tranexamic acid targeting preparation, the steps are as follows:

[0045] (1) Weigh olive oil, cyclopentasiloxane, hydrogenated lecithin, polyglycerol-6 polyhydroxystearate and heat to 60-80°C to obtain the oil phase; weigh deionized water, ammonia Hexamic acid, carbomer, and p-hydroxyacetophenone are heated to 60-80°C to obtain an aqueous phase.

[0046] (2) Mix the oil phase and the water phase, and homogenize in a vacuum homogenizer for 5-15 minutes at a speed of 1000-2000 rpm.

[0047] (3) After vacuum homogenization, start stirring and cool down to 40° C., add papain, vitamin E, and 1.2-hexanediol, and continue stirring to obtain colostrum.

[0048] (4) The colostrum is transferred to a high-pressure homogenizer and circulated for 5-15 weeks at a pressure of 500...

Embodiment 3

[0050] A novel nanometer tranexamic acid targeting preparation, its raw material percentage by weight is as follows:

[0051]

[0052]

[0053] The preparation method of the above-mentioned novel nanometer tranexamic acid targeting preparation, the steps are as follows:

[0054] (1) Weigh sweet almond oil, polydimethylsiloxane, hydrogenated lecithin, polyglycerol-6 polyricinoleic acid ester and heat to 60-80°C to obtain the oil phase; weigh deionized water, aminomethicone Acid, hydroxyethyl cellulose, and sorbic acid are heated to 60-80°C to obtain an aqueous phase.

[0055] (2) Mix the oil phase and the water phase, and homogenize in a vacuum homogenizer for 5-15 minutes at a speed of 1000-2000 rpm.

[0056] (3) After vacuum homogenization, start stirring and cool down to 40° C., add papain and vitamin E and continue stirring to obtain colostrum.

[0057] (4) The colostrum is transferred to a high-pressure homogenizer and circulated for 5-15 weeks at a pressure of 500...

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Abstract

The invention belongs to the field of biochemistry, and particularly relates to a novel nano tranexamic acid targeting preparation and a preparation method thereof. The novel nano tranexamic acid targeting preparation comprises the following raw materials by weight: 5%-30% of a nano lipid targeting material; 2%-20% of tranexamic acid; 2%-10% of an emulsifier; 0.1%-1% of a thickening agent; 0.1%-1% of papain; 0.01%-10% of an effective additive; and the balance of deionized water. The tranexamic acid disclosed by the invention is short in service cycle and high in targeting speed, and the raw materials have more comfortable skin feeling and smaller emulsification particle size, so that the finally obtained nano preparation is more obvious in targeting effect.

Description

technical field [0001] The invention belongs to the field of biochemistry, and in particular relates to a novel nanometer tranexamic acid targeting preparation and a preparation method thereof. Background technique [0002] Melanin is a major factor that determines the color of human skin. Melanin can effectively protect the skin against skin photodamage and photoaging caused by ultraviolet radiation, while excessive accumulation and uneven distribution of melanin can lead to dull skin, chloasma, freckles and age spots generation. Tyrosinase is the main rate-limiting enzyme for melanin synthesis, so regulating the activity of tyrosinase is currently the most researched and applied approach for whitening and lightening spots. Tranexamic acid and tyrosine have similar chemical structures, and they compete to bind tyrosinase, thereby interfering with the normal formation of melanin. Tranexamic acid can also achieve the effect of brightening the skin in the following ways: the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61K38/48A61K47/06A61K47/34A61K47/24A61K47/14A61K47/44A61K9/52A61P17/00B82Y5/00B82Y40/00
CPCA61K31/195A61K38/4873A61K47/06A61K47/34A61K47/24A61K47/14A61K47/44A61K9/5123A61K9/5146A61P17/00B82Y5/00B82Y40/00C12Y304/22002A61K2300/00
Inventor 罗金凤王稹
Owner 杭州拾珍医疗器械有限公司
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