Application of lung-ventilating and toxin-vanquishing prescription to preparation of medicine for preventing and/or treating pneumonia caused by influenza A virus H1N1

An influenza virus and poison formula technology, applied in the new application field of Xuanfei Baidu formula, to achieve the effect of reducing thickening, reducing viral load, and reducing the expression of pro-inflammatory factors

Active Publication Date: 2021-11-30
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently, there are two types of western medicines for the treatment of H1N1 influenza: 1) amantadine drugs (adamantanes and remantadine) and 2) influenza neuraminidase inhibitors (tamiflu oseltamivir and zanamivir zanamivir), however For the treatment of influenza with traditional Chinese medicine, it is still to be studied

Method used

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  • Application of lung-ventilating and toxin-vanquishing prescription to preparation of medicine for preventing and/or treating pneumonia caused by influenza A virus H1N1
  • Application of lung-ventilating and toxin-vanquishing prescription to preparation of medicine for preventing and/or treating pneumonia caused by influenza A virus H1N1
  • Application of lung-ventilating and toxin-vanquishing prescription to preparation of medicine for preventing and/or treating pneumonia caused by influenza A virus H1N1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1 Xuanfeibaidu formula has an effect on the body weight and lungs of mice infected with influenza A (H1N1) virus

[0080] After the mice were modeled and administered in groups, the body weight changes of the mice in each group were observed for 7 days, and the results were as follows: figure 1 As shown, after 3 days of administration, the results of HE staining of mouse lung tissue in each group were as follows: figure 2 shown.

[0081] from figure 1 It can be seen from the figure that compared with the control group, the body weight of the mice in the model group decreased significantly, and compared with the model group, Xuanfei Baidu formula can significantly inhibit the weight loss of the mice infected with influenza virus.

[0082] from figure 2 It can be seen from the figure that the structure of the alveoli in the control group is complete, the shape is regular, and there is no inflammatory cell infiltration in the surrounding tissue (such as f...

Embodiment 2

[0083] Example 2 Effect of Xuanfeibaidu Recipe on the virus titer in the lungs of mice infected with influenza A H1N1 virus

[0084] The PR8-HA mRNA level in the lungs of mice infected with influenza virus was examined by RT-PCR to reflect the virus titer. Compared with the relative titer results of the control group, the lung virus titers of mice in each group were as follows: image 3 Shown (taking the relative titer of the control group as 1). from image 3 It can be seen from the figure that after 3 days of administration, compared with the control group, the virus titer in the lungs of the mice in the model group was significantly increased (P<0.001). Compared with the model group, Xuanfei Baidu formula can significantly reduce the viral load in the lungs of mice infected with influenza virus (P<0.05). It shows that Xuanfeibaidu prescription has the effect of resisting the invasion of H1N1 influenza virus and reducing the virus titer.

Embodiment 3

[0085] Example 3 Effect of Xuanfei Baidu Recipe on the Release of Inflammatory Factors in Mice Infected by Influenza A H1N1 Virus

[0086] The RT-PCR method was used to detect the changes in the mRNA levels of inflammatory factors in the lung tissue of mice infected for 3 days, and the results were as follows: Figure 4 As shown in Figure A to Figure E, it can be seen from the figure that compared with the control group, the mRNA levels of TNF-a, IL-1β, IL-6, IL-10 and Arg-1 in the lung tissue of the model group mice Significantly increased (P<0.05). Compared with the model group, Xuanfeibaidu Prescription significantly reduced the mRNA levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, and also increased the mRNA levels of anti-inflammatory cytokines IL-10 and Arg-1 ( P<0.05). It shows that the Xuanfei Baidu prescription of the present application can reduce the expression of pro-inflammatory factors in the lungs and promote the expression of anti-inflammatory facto...

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Abstract

The embodiment of the invention provides application of a lung-ventilating and toxin-vanquishing prescription or an extract of the lung-ventilating and toxin-vanquishing prescription to preparation of a medicine for preventing and/or treating pneumonia caused by influenza A virus H1N1, wherein the lung-ventilating and toxin-vanquishing prescription comprises the following components in parts by weight: 5-7 parts of raw ephedra, 28-32 parts of gypsum, 28-32 parts of raw coix seeds, 13-17 parts of bitter apricot kernels, 8-12 parts of rhizoma atractylodis lanceae, 13-17 parts of pogostemon cablin, 10-14 parts of artemisia apiacea, 28-32 parts of dried rhizoma phragmitis, 13-17 parts of pummelo peel, 18-22 parts of polygonum cuspidatum, 28-32 parts of verbena, 13-17 parts of semen lepidii and 8-12 parts of raw liquorice. The lung-ventilating and toxin-vanquishing prescription and the extract thereof provided by the invention can reduce the virus load, reduce the expression of proinflammatory factors, promote the expression of anti-inflammatory factors and improve pulmonary symptoms, so that the lung-ventilating and toxin-vanquishing prescription and the extract thereof can be used for preventing and/or treating pneumonia caused by the influenza A virus H1N1.

Description

technical field [0001] The application relates to the technical field of new uses of Xuanfei Baidu prescription, in particular to the use of Xuanfei Baidu prescription in the preparation of medicines for preventing and / or treating pneumonia caused by influenza A (H1N1) virus. Background technique [0002] Influenza A (H1N1) is an acute respiratory infectious disease, and its pathogen is a new type of influenza A (H1N1) virus that spreads among people. Unlike previous or current seasonal influenza viruses, this virus strain contains gene segments from three influenza viruses: swine flu, bird flu and human flu. The crowd is generally susceptible to influenza A (H1N1) virus and can be transmitted from person to person. The early symptoms of human infection are similar to common influenza, including fever, cough, sore throat, body pain, headache, chills and fatigue. Diarrhea or vomiting, muscle pain or tiredness, red eyes, etc. may also occur. [0003] Currently, there are two...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P11/00A61P31/16A61K33/06A61K31/4045A61K31/4706
CPCA61K36/17A61K33/06A61K36/8994A61K36/736A61K36/284A61K36/532A61K36/282A61K36/899A61K36/752A61K36/704A61K36/85A61K36/31A61K36/484A61K31/4045A61K31/4706A61P11/00A61P31/16A61K2300/00Y02A50/30
Inventor 张晗陈璐王彧李玉红赵鑫苗琳张俊华张伯礼高秀梅刘陶王佳宝马琳
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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