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Quality control method for traditional Chinese medicine extraction process
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A control method and process quality technology, applied in measuring devices, material analysis through optical means, instruments, etc., can solve the problems of lack of online quality detection and control methods, and large differences in active ingredient content, so as to improve the quality of traditional Chinese medicine products. Stable quality, saving extraction time, improving stability and uniformity
Pending Publication Date: 2021-12-03
GUANGDONG ZHONGSHENG PHARMA
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At present, the process parameters such as the extraction time of traditional Chinese medicine still rely on manual experience, and there is a lack of effective online quality detection and control methods. Due to the differences in the origin, planting environment, and harvesting methods of Chinese medicinal materials, it is easy to cause the active ingredients in different batches of extracts to be different. There is a large difference in the content of
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Embodiment 1
[0027] refer to Figure 1 to Figure 3 , a kind of Chinese medicine extraction process quality control method, comprises the following steps:
[0028] S1. Put the medicinal material and extraction solvent into the extraction tank for extraction;
[0029] S2. Utilize the near-infrared chromatograph to carry out online detection, detect the content of the index in 60 hours, and calculate the stirring time, calculate and increase the stirring time of the leaching process according to the stirring time, and then repeat the leaching;
[0030] S3. According to the comparison between the detection results of the near-infrared chromatograph and the detection index, whether the target value is reached, if yes, the extraction end point is reached, the extraction is stopped and the extraction solution is collected, if not, the step S1 is repeated.
[0031] Wherein, the medicinal material is Radix Notoginseng medicinal material, and the method for quality control of the extraction process...
Embodiment 2
[0047] Embodiment 2: quality control method of Radix Notoginseng leaching process
[0048] 1) Take 200Kg of Panax notoginseng medicinal material, pulverize it, put it into an extraction tank, add 800L of 55% (v / v) ethanolaqueous solution, seal it, and start timing extraction;
[0049] 2) Stir for 120 minutes at the extraction time of 12 hours, 24 hours, 36 hours, 48 hours, and 60 hours, respectively, and take samples after stirring for 10 minutes to detect the content of the index components in the extract;
[0050] 3) Among them, the contents of 5 index components detected in the leaching time of 60 hours are respectively:
[0051]
[0052]
[0053]4) Calculate the D value, wherein the index component with the largest D value is notoginseng saponin R1, D=8.63%, and the increased stirring time T=e^(a·lnD+b)+c=152 minutes, wherein the T unit is Minutes, a, b, c are constants.
[0054] 5) Prolong the stirring time of 60 hours for 152 minutes, and close the stirring af...
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Abstract
The invention discloses a quality control method for a traditional Chinese medicine extraction process. According to the technical scheme, the quality control method is characterized by comprising the following steps: S1, adding medicinal materials and an extraction solvent into an extraction tank for extraction; S2, carrying out online detection by utilizing a near infrared chromatograph, detecting the content of the index within 60 hours, calculating to obtain the stirring time, calculating to increase the stirring time in the extraction process according to the stirring time, and then carrying out repeated extraction; and S3, comparing a result detected by the near infrared chromatograph with a detection index to determine whether a target value is reached, if so, reaching an extraction end point, stopping extraction and collecting an extraction liquid, and if not, repeating the step S1. According to the traditional Chinese medicine extraction process quality control method, online quality control and terminal point rapid judgment of the traditional Chinese medicine extraction process are realized, the extraction section time, energy and equipment occupancy rate are saved, and the production efficiency is improved.
Description
technical field [0001] The invention relates to the field of traditional Chinese medicinepharmacy, in particular to a method for quality control of the extraction process of traditional Chinese medicine. Background technique [0002] The extraction process of traditional Chinese medicine is the process of dissolving the active ingredients in the raw materials from the traditional Chinese medicinal materials with an appropriate solvent. Dipping extraction is a commonly used extraction method in the production process of traditional Chinese medicine. It is a process of extracting the active ingredients in Chinese medicinal materials by soaking the medicinal materials for a certain period of time at a certain temperature with a quantitative solvent. Usually, multiple dipping extractions are used. At present, the process parameters such as the extraction time of traditional Chinese medicine still rely on manual experience, and there is a lack of effective online quality detecti...
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