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Method for printing porous biological ceramic bone tissue engineering scaffold by utilizing sacrificial material

A technology of bone tissue engineering and bioceramics, applied in the direction of additive processing, ceramic products, applications, etc., can solve the problems of smaller and closed side holes, and achieve the effect of ensuring accurate printing

Pending Publication Date: 2021-12-10
HANGZHOU DIANZI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a method for printing porous bioceramic bone tissue engineering scaffolds by using sacrificial materials, so as to solve the problem that the side holes become smaller or even completely closed due to the sagging of the printed filaments when preparing the bone tissue engineering scaffolds by traditional 3D printing. question

Method used

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  • Method for printing porous biological ceramic bone tissue engineering scaffold by utilizing sacrificial material
  • Method for printing porous biological ceramic bone tissue engineering scaffold by utilizing sacrificial material

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Embodiment 1

[0032] This embodiment relates to a method for printing porous bioceramic bone tissue engineering scaffolds using sacrificial materials, which includes the following steps:

[0033] S1: Build a 3D printing model: Obtain 3D printing models of bone tissue engineering scaffolds with different pore structures through 3D printing technology, and plan the printing path according to the 3D printing models;

[0034] S2: At room temperature (20-30°C), print bone tissue engineering scaffolds layer by layer according to the printing path: use dual nozzles to print synchronously and coordinately, one nozzle ejects filamentous bioceramic material 1, and the other nozzle sprays the filamentous bioceramic material 1 on the adjacent filamentous The support material 2 is ejected between the bioceramic materials 1;

[0035] The support material 2 is a 3D printing ink prepared from an amphiphilic block copolymer. The amphiphilic block copolymer is Pluronic F127. Ronick F127 was dissolved in ice...

Embodiment 2

[0044] The method for printing porous bioceramic bone tissue engineering scaffolds using sacrificial materials in this embodiment is the same as that described in Embodiment 1, and will not be described in this embodiment.

[0045] Refer to attached figure 2As mentioned above, in this embodiment, a total of 12 layers of porous bioceramic bone tissue engineering scaffolds are arranged, and the structure of each layer of porous bioceramic bone tissue engineering scaffolds is the same, 1 bioceramic materials are arranged at intervals, and 2 layers are arranged between adjacent bioceramic materials 1. Root support material 2, layer by layer 90° reverse (the angle of reverse can be set according to the construction of the 3D printing model, this embodiment only illustrates the situation of layer by layer 90° reverse, of course the angle of layer by layer can also be 45° , 60°, etc.), forming a lateral side hole 6.

[0046] Comparing this embodiment with the first embodiment, it c...

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Abstract

The invention discloses a method for printing a porous biological ceramic bone tissue engineering scaffold by using a sacrificial material. The method comprises the following steps: S1, constructing a 3D printing model: obtaining a 3D printing model of a bone tissue engineering scaffold with different pore structures through a 3D printing technology, and planning a printing path; S2, printing the bone tissue engineering scaffold according to the planned path: performing synchronous and coordinated printing by using double nozzles, wherein one nozzle sprays out a filiform biological ceramic material, and the other nozzle sprays out a supporting materials between the adjacent filiform biological ceramic materials; S3, sequentially carrying out air drying and sintering treatment on the printed bone tissue engineering scaffold, and removing the supporting material to form the biological ceramic bone tissue engineering scaffold with different pore structures. In the printing process, the problem that the hole diameter becomes small due to droop of the biological ceramic wires is solved through the supporting material, so that accurate printing of the upper-layer material is guaranteed, and then biological ceramic bone tissue engineering scaffolds of different hole structures can be printed.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a method for printing porous bioceramic bone tissue engineering scaffolds by using sacrificial materials. Background technique [0002] The repair of large bone defects is a worldwide problem. At present, for bone defects with a length greater than 5 cm, a second operation is generally used, which brings great pain to the patient. The implantation of tissue engineering scaffolds can play a bridging role in the defect site, guide the growth of new bone, and then degrade and absorb. Therefore, scaffolds are required to have good mechanical properties and osteoinductive ability, have a degradation rate close to the tissue regeneration rate, and have a sufficiently high porosity. [0003] Bioceramics (hydroxyapatite, tricalcium phosphate, etc.) are very similar to the inorganic components of autologous bone, and have good mechanical strength, biocompatibility, degra...

Claims

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Application Information

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IPC IPC(8): C04B38/06C04B35/622C04B35/447B33Y70/10A61F2/28
CPCC04B38/067C04B35/447C04B35/622B33Y70/10A61F2/28C04B2235/6026C04B2235/606C04B2235/656C04B2235/6562C04B2235/6567A61F2002/2835
Inventor 索海瑞杨翰
Owner HANGZHOU DIANZI UNIV
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