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Face cream composition containing lipid nanoparticles with moisturizing and hydrating effects and preparation method thereof

A lipid nanoparticle and composition technology, applied in the field of daily chemicals, can solve problems such as loss of natural moisturizing factors, damaged skin function, and skin moisture lock, so as to prevent skin moisture loss and promote skin penetration. The effect of delivering and repairing the skin barrier

Pending Publication Date: 2022-01-04
湖北省麦诗特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, there are also damages to the normal function of the skin caused by its own factors, such as natural aging of the skin, excessive cleaning and exfoliation, etc., which lead to damage to skin metabolism, damage to the skin's own moisturizing system, rapid loss of intercellular matrix and natural moisturizing factors, and it is very It is difficult for the skin to lock in moisture, which will lead to long-term dry skin and dehydration problems

Method used

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  • Face cream composition containing lipid nanoparticles with moisturizing and hydrating effects and preparation method thereof
  • Face cream composition containing lipid nanoparticles with moisturizing and hydrating effects and preparation method thereof
  • Face cream composition containing lipid nanoparticles with moisturizing and hydrating effects and preparation method thereof

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Experimental program
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Effect test

Embodiment 1-3

[0057] A face cream composition comprising lipid nanoparticles with moisturizing and water replenishing effects, the proportion and content of raw material components are shown in Table 1 below.

[0058] The raw material composition ratio (unit: mass part) of table 1 embodiment 1-3

[0059]

[0060]

[0061] The preparation process of the face cream comprising the lipid nanoparticles with moisturizing and water replenishing effect of the above-mentioned embodiment 1 comprises the following steps:

[0062] 1) Dissolve 70 mg of sialic acid, 140 mg of Kappa longa cordata extract, and 140 mg of nicotinamide in 5 mL of deionized water to form an inner water phase (W1); mix 500 mg of glyceryl tristearate and Span 80 Dissolve in 15 mL of dichloromethane to form an oil phase; add the inner water phase to the oil phase solution at a volume ratio of 1:3, and use a cell grinder to sonicate for 3 min at a power of 60 W under ice bath conditions to obtain W1 / O-emulsion;

[0063] A...

Embodiment 1

[0086] Test sample: embodiment 1;

[0087] Test method: Use a third-party testing agency to test the safety. Select an area not exceeding 50mm 2 , with a suitable patch device with a depth of about 1mm, add about 0.02-0.025ml (g) of the test substance to the patch test device in a closed patch test method.

[0088] Stick the spot tester on the curved side of the forearm of the subject, remove the test substance after 24 hours, observe the skin reaction at 0.5h, 24h, and 48h after removal, and record the results according to the skin reaction classification standard in "Cosmetic Safety Technical Regulations 2015" .

[0089] Table 2 Patch test results

[0090]

[0091] Remarks: Skin reaction grading standard;

[0092] Level 0: Negative reaction;

[0093] Grade 1: Suspicious reaction; only faint erythema;

[0094] Grade 2: Weak positive reaction (erythema reaction); erythema, infiltration, edema, papules may be present;

[0095] Grade 3: strong positive reaction (herpes...

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Abstract

The invention discloses a face cream composition containing lipid nanoparticles with moisturizing and hydrating effects and a preparation method thereof. The face cream is prepared from the following raw material components in parts by weight: 0.5-13.2 parts of lipid nanoparticles with moisturizing and hydrating effects, 1-14.5 parts of an emollient, 1-12.4 parts of an emulsifying agent, 0.85-11.5 parts of a filling agent, 1-23.8 parts of a thickening agent, 0.1-3.2 parts of a preservative, 0.01-2.6 parts of EDTA-2NA (Ethylene Diamine Tetraacetic Acid-2NA), 0.048-2.4 parts of a pH (Potential of Hydrogen) regulator, 0.075-1.2 parts of daily essence and the balance of de-ionized water. The lipid nanoparticles with the moisturizing and hydrating effects are prepared from the following main components: sialic acid, kappaphycus alvarezii extract and nicotinamide. The effective components selected by the face cream composition are reasonably proportioned, so that the face cream composition has synergistic skin moisturizing and hydrating effects, and the main effective components are wrapped by the lipid nanoparticles, so that transdermal delivery of the effective components is promoted, rapid loss of the effective components is slowed down, the effective components can be slowly delivered to the local part of the skin, and the long-time moisturizing and hydrating effects are achieved.

Description

technical field [0001] The invention relates to a skin care product and a preparation method thereof, belonging to the technical field of daily chemicals, and more specifically relates to a face cream composition containing lipid nanoparticles with moisturizing effect and a preparation method thereof. Background technique [0002] Moisturizing is always the most basic step in skin care. As long as the skin cells drink enough water, the entire face can look healthy and plump. When the skin loses moisture too quickly, it will easily accelerate the aging of the skin, wrinkles, peeling and other problems will appear, making people look tired and lack of energy. [0003] The factors that cause skin dehydration mainly include two aspects. The first is environmental factors that cause skin dehydration. For example, in autumn and winter, the weather is dry, which will cause the water in the stratum corneum to evaporate quickly, and the dry wind will also take away a lot of moisture ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9717A61K8/67A61K8/60A61K8/02A61Q19/00
CPCA61K8/9717A61K8/675A61K8/60A61K8/0245A61Q19/00A61K2800/592A61K2800/413Y02A50/30
Inventor 杨帆周紫燕李沫郭苗周正
Owner 湖北省麦诗特生物科技有限公司
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