The invention relates to a yeast polypeptide cream, and relates to the technical field of skin care products. The cream comprises emollient, surfactant, isopropyl myristate, polydimethylsiloxane, glyceryl stearate, diploid yeast fermentation product lysate, euglena gracilis, hydrolyzed collagen, meadowfoam seed oil, camellia seed oil, sorbitan oleate, carbomer, triethanolamine, glyceryl octanoate,octanoyl hydroxamic acid, propylene glycol and 1,2-hexanediol. the invention is rich in yeast ingredients, can effectively repair the skin barrier, soothe sensitive skin, activate the young skin, rich in camellia and white flower seed oil to nourish the skin, protect the moisturizing effect, Regulates the exudation of water and compounds, reabsorbs water and forms hydrates in the epidermal cellsto lock in moisture in the epidermis of the skin, due to these natural botanical ingredients.