Efficient soothing anti-allergy repair polypeptide composition and application thereof

A soothing and efficient technology, applied in drug combinations, medical preparations containing active ingredients, allergic diseases, etc., to achieve the effect of high mechanism of action, high safety and biological activity, and a clear mechanism of action

Inactive Publication Date: 2021-02-26
ZHEJIANG PEPTITES BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of peptide combination is only aimed at regulating the excessive response of neurosensory and reducing the formation of pro-inflammatory factors. It is not involved in the barrier damage formed by sensitive skin, and has certain limitations in the soothing and repairing of sensitive skin.

Method used

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  • Efficient soothing anti-allergy repair polypeptide composition and application thereof
  • Efficient soothing anti-allergy repair polypeptide composition and application thereof
  • Efficient soothing anti-allergy repair polypeptide composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0034] Examples 1-4 A combination of high-efficiency soothing, anti-allergic and repairing polypeptides, as shown in Table 1.

[0035] Table 1

[0036]

[0037] Configuration method: Add the carbomer in the formula amount to water and butanediol, stir to mix evenly, let it stand for 24 hours, stir for 5-10 minutes, until a uniform solution without particles, follow the example below 40°C Add the polypeptide uniformly dispersed in polysorbate-20 in sequence with the comparative example, stir evenly, and adjust the pH value to about 5.0 with sodium lactate.

Embodiment 1

[0077] Take Example 1 and Comparative Example 10 polypeptide composition for experimental comparison, and use water as a blank placebo control to evaluate the effect of antipruritic and redness reduction;

[0078] Organize 20 volunteers, respectively apply 20uL of 1% histamine phosphate to the skin area of ​​3×3cm of the volunteers’ arms, wait for the skin to become red and itchy, and record the time; then drop 0.1% diluted samples of Example 1 and Comparative Example 10 20uL each of the sample and water were placed in the test area, and the red itching subsided time was recorded.

[0079] Test site: inner arm

[0080] Test environment: temperature: 20℃~22℃, humidity: 40%~60%

[0081] Reference basis for skin erythema: GB17149.2-1997 Determination of the degree of reaction of the test site;

[0082] Itching refers to the evaluation and countermeasures of skin itching in patients with skin diseases;

[0083]

[0084] The experimental results are shown in Table 5

[0085]...

Embodiment 2

[0089] Taking Example 2, the commercially available glycerol phosphoinositide choline salt is used for experimental comparison, and water is used as a blank placebo control to evaluate the antipruritic and redness-relieving effects;

[0090] Organize 20 volunteers, respectively apply 20uL of 0.8% histamine hydrochloride to the 3×3cm area of ​​volunteers’ arm skin, wait for the skin to become red and itchy, and record the time; then drop 0.1% diluted sample of Example 2 and glycerol phosphate Each 20uL of the alcohol choline salt sample and water was placed in the test area, and the red itching subsided time was recorded.

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PUM

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Abstract

The invention discloses an efficient soothing anti-allergy repair polypeptide composition and an application thereof. The efficient soothing anti-allergy repair polypeptide composition provided by theinvention comprises acetyl heptapeptide-4, oligopeptide, palmitoyl tripeptide-8, palmitoyl tetrapeptide-7, heptapeptide-6, 10-30% of butanediol, glycerol, water, carbomer and sodium lactate, and a pHrange is 4.0-6.0. The polypeptides in the composition can have effective synergistic effects, and compared with a single polypeptide and a combination of part of the polypeptides in the composition,the polypeptide composition has more effective anti-allergy repair effects and shows obvious synergistic effects. The anti-allergy repair polypeptide composition covers three aspects of a skin sensitivity forming mechanism, has a brand-new barrier repair mechanism, effectively regulates and controls sensory nerve overreaction and reduces inflammatory aging, and therefore is an ideal and comprehensive anti-allergy repair product.

Description

technical field [0001] The invention relates to the technical field of cosmetics. More specifically, the present invention relates to a combination of high-efficiency soothing and anti-allergy repairing polypeptides and its application. Background technique [0002] With the increasing environmental pollution and mental stress, the incidence of sensitive skin is gradually increasing in countries all over the world, seriously affecting people's quality of life, especially in developed countries such as Japan and the United States, skin sensitivity has become a social issue that affects human health. question. According to incomplete statistics, there are more and more people around the world who feel sensitive skin, of which 38% are men and 61% are women. It can be seen that there is a huge market demand for skin care for sensitive skin. [0003] Sensitive skin, also known as sensitive skin syndrome, refers to skin with poor tolerance, high reactivity or sensitization. Ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61Q19/00A61P37/08A61P17/00
CPCA61K8/64A61Q19/00A61Q19/005A61P37/08A61P17/00A61K2800/782A61K2800/5922
Inventor 黄毅邢海英刘志国虞新友
Owner ZHEJIANG PEPTITES BIOTECH CO LTD
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