Method for training and improving space learning ability of mice

Abstract

The invention provides a method for training and improving the space learning ability of mice. The method comprises the following steps: training the mice by using a water maze for 30 days twice a day, performing repeated measurement variance analysis on the incubation period of the DBA / 2 mice before an experiment and after the experiment, performing analysis on the incubation period of the DBA / 2 mice and the incubation period of the C57BL / 6 mice by using an independent sample t test, and realizing improvement effect evaluation of the space learning ability of the DBA / 2 mice. The invention also provides application of mouse Nr1d1 genes to improvement of the space learning ability of the mice. According to the invention, the improvement of Morris water maze training on the space learning ability of the DBA / 2 mice is doubly measured, and a molecular biological evaluation marker which can be used as a training or drug to improve the space learning ability of the mice is provided.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a method for training and improving the spatial learning ability of mice. Background technique [0002] Spatial learning and memory is a behavioral pattern that detects spatial orientation, reaction time, visual perception, and structural application to evaluate its cognitive level. It is a type of learning and memory about scenes and time. The Morris Water Maze (MWM) is a device designed by the British psychologist Morris in the early 1980s for the study of spatial learning and memory in rodents. Previous studies have used MWM as a test method for animal spatial learning and memory, and there are few Focus on the effect of repeated MWM training on the spatial learning and memory abilities of the animals themselves. In fact, the effect of repeated MWM training on the ability of spatial learning and memory has very important practical significance. In real life, the abil...

AI Technical Summary

Problems solved by technology

[0004] Previous studies have found that repeated exposure to spatial learning stimuli can improve the subsequent spatial learning ability of animals, but there is a lack of further research on the expression of genes in the hippocampus that are related to the promotion of spatial learning ability in mice at the molecular level, and most of them have passed Comparing the performance of animals in training before and after to evaluate their spatial learning ability, not using animals with stronger spatial learning ability as a benchmark

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