Method for synchronously measuring reaction gas production rate during reaction calorimetry

Abstract

The invention discloses a method for synchronously measuring a reaction gas production rate during reaction calorimetry. The method employs a measuring device, and the measuring device comprises a U-shaped pipe and a pressure sensor, wherein the U-shaped pipe comprises a left branch pipe and a right branch pipe, indicating liquid is injected into the U-shaped pipe to seal the left branch pipe and the right branch pipe, the right branch pipe is communicated with the outside, and the left branch pipe is provided with an exhaust port and a gas inlet communicated with a reaction calorimeter. The method comprises the steps that the gas inlet is opened at first and the exhaust port is closed to enable gas generated in the reaction calorimeter to enter the left branch pipe, when the pressure sensor detects that the pressure in the left branch pipe reaches a preset pressure value, the gas inlet is closed and then the exhaust port is opened, the amount of substance of the gas discharged in a single time is calculated, the steps are repeated until the reaction is finished, and the total substance amount of the discharged gas is accumulated to obtain, and the gas production rate is obtained according to the reaction time. According to the method, reaction calorimetry and measurement of reaction produced gas are carried out at the same time, and the limitation that a large measuring device is needed when the produced gas is too much is avoided.

Description

technical field [0001] The invention relates to the technical field of reaction gas production measurement, in particular to a method for synchronously measuring reaction gas production rate during reaction calorimetry. Background technique [0002] A reaction calorimeter is a tool used in chemical and pharmaceutical development to measure the heat released or absorbed by a chemical or physical reaction. [0003] While measuring the heat release or heat absorption, it is often necessary to measure the gas produced by the chemical reaction, so as to analyze the chemical reaction process through the gas production and gas production rate. Currently, the U-shaped tube is used to measure the gas produced during the reaction process. The method of gas volume and gas production rate, but it usually needs to be carried out after the reaction calorimetry is over. During the reaction process, the device is in a sealed state, and the air pressure in the device changes greatly, which w...

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Problems solved by technology

[0003] While measuring the heat release or heat absorption, it is often necessary to measure the gas produced by the chemical reaction, so as to analyze the chemical reaction process through the gas production and gas production rate. Currently, the U-shaped tube is used to measure the gas produced during the reaction process. The method of gas volume and gas production rate, but it usually needs to be carried out after the reaction calorimetry is over. During the reaction process, the device is in a sealed state, and the air pressure in the device changes greatly, which will easily lead to deviations in the experimental and measurement results; therefore, this method is used The accuracy of the results measured by the method is not high, and the real-time monitoring of the gas production rate cannot be realized. In addition, when the gas production is too much during the reaction process, in order to accommodate more gas, a larger U-shaped tube (measuring device) is required. The measurement process is inconvenient

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