Devices, systems and methods for the treatment of abnormal tissue

Abstract

Devices, systems and methods are provided to treat damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) by delivering specialized pulsed electric field (PEF) energy to target tissue areas. The energy is delivered in a manner so as to be non-thermal (i.e. below a threshold for causing thermal ablation). Consequently, when extracellular matrices present, the extracellular matrices are preserved, and the targeted tissue maintains its structural architecture including blood vessels and lymphatics. Thus, sensitive structures, such as biological lumens, blood vessels, nerves, etc, are preserved which are critical to maintaining the integrity and functionality of the tissue. The energy is delivered with the use of systems and devices advantageously designed for superior access to target tissue throughout the body, particularly in locations previously considered inaccessible to percutaneous approaches.

Description

[0001] cross reference [0002] This application claims priority to and claims the benefit of U.S. Patent Application No. 62 / 835,846, filed April 18, 2019, entitled "Tissue Treatment From Within Luminal Structures," which The disclosure is incorporated herein by reference in its entirety. Background technique [0003] Abnormal tissue can take many different forms, such as damaged, diseased, obstructed, cancerous, or unwanted tissue. In some instances, the abnormal tissue is a tumor, such as a benign or malignant tumor, a cyst, or an area of ​​diseased tissue. One of the most troublesome types of abnormal tissue is associated with cancer. [0004] Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. Although the causes of cancer are not fully understood, many factors are known to increase the incidence of the disease, including many modifiable factors (for example, smok...

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