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Method and composition for treating cancer or skin lesion using vaccine

A technology for compositions and vaccines, applied in the directions of drug combinations, biochemical equipment and methods, viruses, etc., can solve problems such as the use of vaccines that are not described, and achieve the effect of reducing the incidence of recurrence

Pending Publication Date: 2018-11-23
HPVVAX LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Although the US'979 and US'538 publications describe the use of therapeutic vaccines against skin cancers such as SCC or epithelial SCC, they do not describe the use of vaccines against other skin cancers such as BCC or melanoma, which This may be based on the knowledge that BCC and melanoma are not associated with HPV infection

Method used

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  • Method and composition for treating cancer or skin lesion using vaccine
  • Method and composition for treating cancer or skin lesion using vaccine
  • Method and composition for treating cancer or skin lesion using vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0195] Example 1 - Skin Cancer

[0196] The following graphs present the results from the treatment method of the present invention implemented in three patients experiencing relatively frequent recurrence rates of skin cancers, including squamous cell carcinoma (SCC) as well as basal cell carcinoma.

[0197] The data presented below represent the mean number of differential recurrences of skin cancer per month over a period of time before and after undergoing the treatment methods described herein.

[0198] A.Patient 1

[0199] Patient 1 was given three 0.5 ml doses comprising a first 0.5 ml dose, a second 0.5 ml dose two months later, and a third 0.5 ml dose four months after the second dose. At a follow-up examination three months after administration of the third dose of HPV quadrivalent (types 6, 11, 16, and 18) recombinant vaccine, Patient 1 experienced zero cutaneous Cancer (including two types of SCC and BCC) recurrence. Patient 1 had more than 300 different ski...

Embodiment 2-

[0214] Example 2 - Breast Cancer

[0215] A 32-year-old woman, previously vaccinated against HPV, with no history of breast cancer, no family history, and no risk factors, was diagnosed with metastatic breast cancer. Her main tumor was approximately 4.1 cm in diameter as measured by ultrasound. These metastatic tumors can double in size in about 12 weeks.

[0216] With the patient's full informed consent and understanding, the tumor was injected directly with a standard initial dose (about 0.5 ml) of a commercially available HPV vaccine. About two weeks after the first injection, a second dose of 0.5 ml diluted to about 3 ml with saline and lidocaine was administered directly to the tumor. At that time, it was more difficult to find the tumor to inject, and it is believed to have decreased in size.

[0217] A recent follow-up ultrasound showed a reduction in size of the tumor to approximately 2.7 cm in diameter, corresponding to an approximately 35% reduction in diameter,...

Embodiment 3

[0219] Example 3 - Metastatic Basal Squamous Cell Carcinoma

[0220] A 99-year-old woman presented with metastatic basal squamous cell carcinoma of the leg. Metastatic basal squamous cell carcinoma, severe enough to refer her to dermatology for palliative care, and with no other option but amputation of a limb to prevent further spread of the cancer.

[0221] Patients are given intramuscular (systemic) a single injection of a conventional dose (approximately 0.5 ml) of a commercially available HPV vaccine. An additional standard dose of HPV vaccine is injected into each of two or more sites of the larger lesion.

[0222] Within four weeks of treatment with the HPV vaccine, the lesions had largely improved visually, and the cancer had not spread further in the legs. The patient is currently in remission from a further or increased size of the lesion.

[0223] Example 4 - Penile Cancer

[0224] A 45-year-old HIV-positive man with a two-year history of squamous cell carci...

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Abstract

A method for treating or reducing the incidence of recurrence of cancer, benign tumors or HPV-associated lesions, including skin cancer, and particularly squamous cell carcinoma (SCC) and basal-cell carcinoma, by administering one or more doses of HPV recombinant vaccine to a patient.

Description

technical field [0001] The present invention relates to the treatment of cancer, including skin cancer or benign or malignant tumors, and more particularly to methods for treating cancer or tumors or reducing the incidence of recurrence thereof comprising the administration of a vaccine, including the administration of a vaccine comprising the vaccine The composition is administered topically as a therapeutic agent. Background technique [0002] Skin cancer consists of three main types: basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma, and is the most common form of cancer in the world. Understandably, research has continued over the years to find effective ways to treat and possibly cure these types of skin cancer. [0003] It is generally accepted that human papillomavirus (HPV) is implicated in causing certain types of skin cancer, particularly squamous cell carcinoma (SCC). HPVs are DNA viruses that can infect certain types of tissue in humans. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/12C07K14/005C12N7/00
CPCA61K39/12A61K2039/545C12N2710/20034A61P35/00A61P31/20C07K14/005C12N7/00A61P23/02A61K35/76A61K45/06A61K2039/54
Inventor 蒂姆·艾恩尼德斯
Owner HPVVAX LLC
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