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NANO flow sensors

A sensor, flow technology, applied in/method development, the field of battery life, can solve the problems of cumbersome, error-prone, long time, etc.

Pending Publication Date: 2022-02-25
BOARD OF RGT THE UNIV OF TEXAS SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For sub-μL / min flow rates, this method becomes tedious and error-prone, and takes a very long time for a single measurement

Method used

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  • NANO flow sensors
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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0054] Example 1: Capillary Observation Tubes - Making Silica Capillary Walls Fluorophilic

[0055] Silica capillaries of different inner diameters and an outer diameter of 360 μm were used as observation tubes. However, unless otherwise stated, all data reported here relate to 11 μm ID, 35 cm long polyimide coated fused silica capillaries.

[0056] To make the fluorophilic wall, the capillary was washed sequentially with 0.1M ethanol KOH, water, 0.1M HCl, and water, each step took about 15 minutes, and finally filtered dry N 2 Blow it through to dry and suck the TCPFOS into it and let it react overnight. use N 2 After flushing the spent / excess reagents, flush the capillary with FC. A comparison of the air-fluorocarbon interface between untreated and TCPFOS-treated fused silica capillaries indicated that the contact angle of FC decreased significantly after TCPFOS treatment. Figure 8A and Figure 8B The larger bore 180 μm capillary and the aqueous phase stained with me...

example 2

[0057] Example 2: Generation of multi-segment fluid flow markers

[0058] The procedure for setting up multi-segment flow markers includes providing simultaneous monitoring of flow through the reference method, as follows. In this example, mercury was used because it provides a very visible marker under the microscope. The reference and measurement segments - separated by 1 cm - consisted of a ~2 mm mercury segment in the middle of the test fluid and a string of FC / AA / FC (~5 / 2 / 5 mm in length) as multi-segment markers, respectively.

[0059] To help achieve at least approximately the desired marker length, a 10 cm length of capillary was marked every mm with a fine-tipped marker. All liquids were introduced into the capillary with dedicated 1 mL syringes using appropriate luer adapters to threaded unions. The flow cell is first filled with test fluid (TF). Then, 2mm Hg, 1cm TF, 5mm FC, 2mm AA and 5mm FC were injected sequentially. In all cases, the amount of liquid initia...

example 3

[0066] Example 3: Detection method

[0067] optical detector

[0068] To measure smaller flow rates, the observation tube was a 28 μm inner diameter clear cyclic olefin polymer (COP) capillary; a 10 μL syringe was used for FC delivery and a custom zero dead volume capillary tee was used. Fluorocarbon water interfaces are not discernible even with the smallest optical slits. If the transmission through the aqueous phase is reduced by incorporating a high concentration of dye, the interface can be seen by the detector.

[0069] Using a mercury segment with FC on the side, a reflective interface detection method is explored. This detector construction is very simple and cheap since it does not require special optical aperture or slit arrangements. Initial experiments clearly indicated that the Hg-FC interface was easily detected even in capillaries of 11 μm inner diameter. In some embodiments, further contrast between light reflected by the metal surface and light scattered...

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PUM

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Abstract

A flow meter comprises a capillary, a first and second fluid flow marker, and one or more sensors. The capillary has a longitudinally extending fluid receiving space, with a first end and a second end. The first and second fluid flow markers are immiscible and are positioned in the fluid receiving space. The one or more sensors are positioned along the capillary. A method for measuring flow rates comprises the steps of introducing a first liquid into a flow meter. That first liquid flows into the fluid receiving space at the first end of the capillary thereby displacing the first fluid flow marker and the second fluid flow marker towards the second end of the capillary. The interface between the first fluid flow marker and the second fluid flow marker is measured with one or more sensors to determine the flow rate of the first liquid.

Description

[0001] Cross References to Related Applications [0002] This application hereby claims the benefit of Provisional Patent Application Serial No. 62 / 875,685 of the same title filed on July 18, 2019, the disclosure of which is incorporated herein by reference in its entirety. [0003] Statement Regarding Government Funding [0004] This invention was made with government support under grant number NNX15AM76G awarded by NASA and CHE-1506572 awarded by the National Science Foundation. The Government reserves certain rights in this invention. Background technique [0005] With the exception of microfluidic systems, many current analytical methods at the capillary scale operate at flow rates below 25 nL / min. Recent examples include open-tube ion chromatography columns with van Deemter optimum at 18 nL / min, LC-MS / MS systems based on packed 25 μm ID columns operating at ≤10 nL / min, operating at 5 nL / min Open-tube reversed-phase LC separation into a 2 μm id column operated at a flow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01F1/661G01F1/56G01F1/7086
CPCG01F1/661G01F1/56G01F1/7086G01F1/704G01N2030/324G01F1/58G01F1/708G01F15/005G01N21/6428G01N2021/6439
Inventor 普南杜·达斯古普塔秦楚楚
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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