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Application of dulatide in preparation of antitumor drugs

An anti-tumor drug, dulaglutide technology, applied in the field of tumor treatment, can solve the problem of no immune activation or anti-tumor immune activation data or results, no dulaglutide tumor treatment or anti-tumor and other problems, to delay metastasis The effect of recurrence, inhibition of tumor growth, and prolongation of survival

Pending Publication Date: 2022-03-04
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report on the use of dulaglutide for tumor treatment or anti-tumor, and there is no report on its immune activation or anti-tumor immune activation data or results

Method used

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  • Application of dulatide in preparation of antitumor drugs
  • Application of dulatide in preparation of antitumor drugs
  • Application of dulatide in preparation of antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Immunoactive function of detecting polypeptide drugs on peripheral blood mononuclear cells

[0024] First, experimental method

[0025] 1. Screening the determination of the object

[0026] We use the DrugBank database to retrieve polypeptide drugs, exclude FDA-approved polypeptides for infectious disease treatment, blood system disease treatment, tumor therapy, and immunomodulatory polypeptides, and tumor therapy and immune regulation of these polypeptides. Relationship. Function is concentrated in the treatment of hormone disorders, therapeutic dysfunction, treatment of diabetes, treating gastrointestinal gastrointestinal diseases, treating hereditary diseases, treating cardiovascular disease, cure bone disease, treating nervous system disease, treating breathing disorders, treating eye disorder Admitness. This includes polypeptide drugs for diabetes treatment. In addition, it also retrieved the unique polypeptide drug for diabetes treatment in China. After summ...

Embodiment 2

[0036] Example 2 Normal mouse melanoma model observed the therapeutic effect of the degree of sugar peptide

[0037] First, experimental method

[0038] We use normal healthy mice C57BL / 6, mice immunogenous, blood sugar is normal, mainly in mice (melanoma model) in mice (melanoma model) in immunogenic, blood sugar, then observe the treatment and immuno activation. Since it is a mouse in mice in immunogenic, blood glucose, if the degree sugar peptide is effective, then such a function does not depend on its existing function - lowering blood sugar.

[0039] The 6-8 weeks of age C57BL / 6 mice were selected, and the subcutaneous melanoma model was established on the right armpit. 5 × 10 per mouse side 6 B16 / F10 melanoma cells, measured tumor size to about 200mm after about 6 days 3 The mice were randomly divided into 2 groups, each group of 12, respectively: PBS control group (100 μl PBS) and degrees pulled sugar peptide skin injection treatment group (the degree per sugar pepti...

Embodiment 3

[0046] Example 3 Treatment effect of observation of degrees pulled sugar peptide skin under normal mouse breast cancer model

[0047] First, experimental method

[0048] We choose normal healthy BALB / C female mice, mice immunogenic, blood sugar is normal, mainly in mice (breast cancer models) in mice (breast cancer models) in immunogenic, blood sugar, then observe the treatment and immuno activation . Since it is a mouse in mice in immunogenic, blood glucose, if the degree sugar peptide is effective, then such a function does not depend on its existing function - lowering blood sugar.

[0049] The 6-8 weeks old BALB / C female mice were selected, and the subcutaneous breast cancer model was established at the right armpit. 5 × 10 per mouse side 6 Mouse 4T1 breast cancer cells, measured tumor size to about 200mm after 8 days 3 The mice were randomly divided into 2 groups, each group of 12, respectively: PBS control group (100 μl PBS) and degrees pulled sugar peptide skin injectio...

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Abstract

The invention relates to the field of tumor treatment, in particular to application of dulatide in preparation of anti-tumor drugs. The invention discloses the effect of dulatide in the aspect of immune activation and the effect of dulatide in the aspect of anti-tumor immune activation. The invention further discloses the effect of the dulatide in the aspect of anti-tumor immunotherapy. Results of the invention show that dulatide can significantly stimulate immune cell proliferation, and can significantly stimulate release of interferon gamma (IFN-gamma); on a plurality of in-vivo animal tumor-bearing models, dulatide can significantly inhibit tumor growth and significantly prolong the lifetime of tumor-bearing mice; the dulaglycopeptide can obviously prolong the lifetime of mice after metastatic and recurrent tumor operation, and the dulaglycopeptide is a drug on the market, so that the safety of the dulaglycopeptide is basically guaranteed. In short, the dulatide can be used for preparing antitumor drugs.

Description

Technical field [0001] The present invention relates to the field of tumor treatment, in particular to the immunoharging effects and anti-tumor use of the syndrope of the syndrope. Background technique [0002] Tumors are major diseases that threaten human health. Conventional surgery, radiotherapy, chemotherapy, etc. inhibit the progression of tumors to a certain extent, but it is difficult to control the recurrence of tumors and transfer. With the emergence of exciting clinical research, anti-tumor immunotherapy brings hope to patients with tumor. The immune system has the ability to identify and remove abovers, but the tumor is not only a congenital immune response of the immune system during development, but also limits the "new" antigen "display" and launch immunoamental points. Immune effect cells come to "paralyzed" infiltration, thereby achieving the purpose of escapeing of epidemic recognition and immunization. How to effectively activate anti-tumor immune responses, rel...

Claims

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Application Information

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IPC IPC(8): A61K38/26A61P35/00A61P35/04A61P37/02
CPCA61K38/26A61P35/00A61P35/04A61P37/02
Inventor 吴俊华刘淑雯魏继武江春平张姗石维维马丁王忠夏张广曹胤
Owner NANJING UNIV
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