Bionic three-layer artificial blood vessel and preparation method thereof

An artificial blood vessel and coating technology, which is applied in the field of bionic three-layer artificial blood vessel and its preparation, can solve the problems of bleeding, operation failure, and inability of cells to effectively crawl and grow, and achieve good biological safety, smooth blood flow, and benefit Effects of invasion and growth

Pending Publication Date: 2022-03-08
SHANDONG HUANGHE DELTA INST OF TEXTILE SCI & TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem with it is that there are large pores between the fibers and the fiber layers, which will cause bleeding after the artificial blood vessel is implanted, and induce inflammation and cause the operation to fail. Rejection occurs

Method used

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  • Bionic three-layer artificial blood vessel and preparation method thereof
  • Bionic three-layer artificial blood vessel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A method of preparation of a bionic three-story artificial blood vessel, including the following steps:

[0039] (1) Polyurethane tubular film formation

[0040] 10 g of polyurethane particles were placed in 90 g of, N-dimethylformamide, and stirred at 70 ° C for 4H to 8 h at a rate of 500 r / min. After it was completely dissolved, it was completely dissolved to obtain a uniformly transparent polyurethane solution, which will stir well polyurethane The solution was poured into a 20 cm tube to deriviate the degree of -0.1MPa ~ -0.06 MPa environment, and a homogeneous polyurethane solution was obtained.

[0041] The smooth mold of 9.1mm in diameter is slowly inserted into the polyurethane solution to stand for 3 minutes and then slowly take out the inserted distilled water, the solvent N, N-dimethylformamide in the polyurethane solution is precipitated from polyurethane, and the polyurethane is solidified on the glass rod. The film, the backlight is naturally 12H to 24 h, an...

Embodiment 2

[0062] A method of preparation of a bionic three-story artificial blood vessel, including the following steps:

[0063] a. Polyurethane tubular film film formation

[0064] The 15 g of polyurethane particles were placed in 85 gn, N-dimethylacetamide, stirred in a water bath in a water bath in a water bath in a water bath of 500 r / min, and a uniform transparent polyurethane solution was completely dissolved, and agitated polyurethane The solution was poured into a 20 cm tube to deriviate the degree of -0.1MPa ~ -0.06 MPa environment, and a homogeneous polyurethane solution was obtained.

[0065] The smooth mold of 9.1mm in diameter is slowly inserted into the polyurethane solution to stand for 3 minutes and then slowly take out the inserted distilled water, the solvent N, N-dimethylformamide in the polyurethane solution is precipitated from polyurethane, and the polyurethane is solidified on the glass rod. The film, the backlight is naturally 12H to 24 h, and the film is dried in...

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Abstract

The invention belongs to the technical field of medical instrument surgical implants, and particularly relates to a bionic three-layer artificial blood vessel and a preparation method thereof. The artificial blood vessel is of a three-layer composite structure and sequentially comprises a polyurethane tubular film, an artificial blood vessel reinforcing body and an outer wall coating from inside to outside, polyurethane is selected as a blood vessel preparation raw material for the inner layer, and the polyurethane material is good in biocompatibility and excellent in elasticity, can guarantee smooth blood flowing and reduce thrombus generation and has good weather resistance; the service life is long; the middle layer is made of tubular fabric, is a smooth muscle tissue imitating the blood vessel middle layer, and plays a role in increasing the support of the blood vessel prosthesis and increasing the strength; the outer wall coating simulates blood vessel outer wall connective tissue, and invasion and growth of tissue cells are facilitated. The artificial blood vessel provided by the invention has good biocompatibility and high impermeability, and the success rate of an operation can be improved.

Description

Technical field [0001] The present invention belongs to the technical field of medical device surgical implant, and more particularly to a biostile three-layer artificial blood vessel and a preparation method thereof. Background technique [0002] At present, with the improvement of people's living standards, the incidence of vascular diseases is more frequent, and vascular transplant is the most effective method for treating vascular diseases. The body transplant is the safest way, but the source is limited, and a large number of artificial blood vessels need to be replaced by the damaged blood vessel. [0003] The human body's own blood vessel is divided into three layers: the innermost layer is the film structure composed of endothelial cells, the intermediate layer is the oriented smooth muscle tissue, and the outermost layer is a connective tissue. Smooth muscle cells are blood vessel support layers, and the kinetic energy and potential can be quickly transformed during the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/22A61L27/50A61L27/58A61F2/06A61F2/07
CPCA61L27/18A61L27/227A61L27/222A61L27/507A61L27/58A61F2/06A61F2/07A61L2400/18C08L75/04C08L89/00
Inventor 孙涵房宽峻刘玉杰杨毅朱蕾李屹杭刘迪王侠张靖宇
Owner SHANDONG HUANGHE DELTA INST OF TEXTILE SCI & TECH RES INST
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