Application of GSK126 in preparation of medicine for treating oxaliplatin drug-resistant colon cancer

A technology for oxaliplatin and colon cancer, which is applied in the field of preparation of drugs for the treatment of oxaliplatin-resistant colon cancer. Effect of tumor growth and promotion of apoptosis

Pending Publication Date: 2022-03-11
CENT SOUTH UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

GSK126 (GSK2816126) began to enter phase I clinical trials to evaluate the treatment of various lymphomas, solid tumors and multiple myeloma. However, due to poor membrane permeability and poor drug excretion by transporters, GSK126 does not seem to be For ora

Method used

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  • Application of GSK126 in preparation of medicine for treating oxaliplatin drug-resistant colon cancer
  • Application of GSK126 in preparation of medicine for treating oxaliplatin drug-resistant colon cancer
  • Application of GSK126 in preparation of medicine for treating oxaliplatin drug-resistant colon cancer

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[0016] In order to make the technical problems, technical solutions and advantages to be solved, the technical solutions and advantages will be described in connection with the accompanying drawings and specific examples, but the scope of the invention is not limited to the following specific embodiments.

[0017] All of the professional terms used hereinafter are identical to those skilled in the art, unless otherwise defined. It is not intended to limit the scope of the invention.

[0018] Source of experimental cells: Human colorectal cancer Nio Sali platinum cell line HCT116 / L-OHP is purchased from Shanghai Meixuan Biotechnology Co., Ltd., maintains steady state in RPMI-1640 medium containing 25μm Osli.

[0019] Experimental animal Source: BALB / C Nude Mouse is purchased in the Experimental Animal Science Department of Central South University, SPF level.

[0020] CCK8 detection of cell vitality

[0021] After the wall is digested, inoculated in a 96-well plate at a density...

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Abstract

The invention belongs to the field of biological medicines, and particularly relates to application of GSK126 in preparation of a medicine for treating oxaliplatin-resistant colon cancer. A colorectal cancer oxaliplatin-resistant cell strain HCT116/L-OHP is constructed, GSK126 and oxaliplatin are combined to intervene colorectal cancer oxaliplatin-resistant cells, the drug-resistant cells can be sensitive to oxaliplatin, cell apoptosis is promoted, animal experiments further prove that tumor growth can be effectively inhibited through combination of GSK126 and oxaliplatin, and the drug-resistant cells can be used for inhibiting tumor apoptosis. And the sensitivity of the oxaliplatin-resistant CRC tumor to the oxaliplatin is recovered.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of GSK126 in the preparation of drugs for treating oxaliplatin-resistant colon cancer. Background technique [0002] Colorectal cancer is a malignant tumor that evolves from the epithelial tissue of the colon or rectum, and it is one of the most common malignant tumors in the world. It is estimated that by 2030, the global burden of colorectal cancer will increase by 60%, with more than 2.2 million new cases and 1.1 million cancer deaths. In recent years, with the continuous development of new and effective anticancer drugs, the mortality rate of colorectal cancer patients has decreased, but the five-year survival rate is still very low. [0003] Currently, commonly used treatments for colorectal cancer patients include surgery, radiation, chemistry, immunity, and biomolecular targeting. Surgical resection combined with standard adjuvant chemotherapy strate...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/555A61P35/00A61P1/00
CPCA61K31/496A61K31/555A61P35/00A61P1/00A61K2300/00
Inventor 殷刚曙光刘佳鑫李医民甘亚琦
Owner CENT SOUTH UNIV
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