Florfenicol soluble powder and preparation method thereof

A florfenicol and soluble technology, which is applied in the field of florfenicol soluble powder and its preparation, can solve the problems of difficult absorption in the digestive tract, uneven dispersion, and affecting solubility, etc., and achieves good quick release effect and high solubility Good, good stability
CN114209656AActive Publication Date: 2022-03-22ZHEJIANG LANGBO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG LANGBO PHARMA
Publication Date
2022-03-22

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Abstract

The invention belongs to the field of veterinary drugs, and particularly relates to florfenicol soluble powder and a preparation method thereof. The florfenicol soluble powder is prepared from the following components in parts by weight: 200 to 300 parts of florfenicol, 100 to 150 parts of a surfactant, 200 to 250 parts of an inclusion agent, 150 to 300 parts of a cosolvent, 50 to 100 parts of a stabilizer, 400 to 500 parts of an organic solvent and 1000 parts of pure water. The florfenicol soluble powder provided by the invention is good in solubility, can be uniformly dispersed in fluid (such as water), is good in dissolution, good in quick release effect, very small in influence of water temperature, convenient to use and good in stability.
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Description

technical field

[0001] The invention belongs to the field of veterinary medicine, in particular to a florfenicol soluble powder and a preparation method thereof. Background technique

[0002] Florfenicol (florfenicol, FF), also known as fluthiamphenicol and fluprofen, is a white or off-white crystalline powder, odorless and bitter. Molecular formula is C 12 h 14 Cl 2 FNO 4 S, the chemical structural formula is as follows:

[0003]

[0004] Florfenicol is a new generation of chloramphenicol-type veterinary-specific broad-spectrum antibiotics developed by Schering-Plough in the late 1980s. It has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, high efficiency and safety, etc. The treatment effect of poultry bacterial diseases caused by it is remarkable, and it has effects on both Gram-positive bacteria and negative bacteria.

[0005] Florfenicol is a time-dependent drug, and its bactericidal effect mainly depends on...

Claims

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