Penis albuginea repairing patch with double-layer structure and preparation method thereof

A technology of double-layer structure and layer structure, applied in the direction of prosthesis, tissue regeneration, medical science, etc., can solve the problems of graft shrinkage, structure mismatch with natural tunica albuginea, immune rejection, etc., to promote the recovery of reproductive function, Excellent long-term performance, good biosafety effect

Active Publication Date: 2022-03-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although certain effects can be achieved, these materials also have problems such as donor site complications, limited sources, mismatch between structure and natural buffy coat, immune rejection, and graft shrinkage, making it difficult to carry out large-scale clinical promotion and application.

Method used

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  • Penis albuginea repairing patch with double-layer structure and preparation method thereof
  • Penis albuginea repairing patch with double-layer structure and preparation method thereof

Examples

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Effect test

preparation example Construction

[0033] The present invention also provides a preparation method for the above-mentioned double-layer structure albuginea repair patch, comprising the following preparation steps:

[0034] 1) dissolving polyvinyl alcohol (PVA) in PBS solution or deionized water to obtain a certain mass fraction of the PVA solution;

[0035] 2) Pour the PVA solution obtained in step 1) into a flat mold of a certain shape, freeze at -20°C for 3 hours, take it out and rewarm it at room temperature for 3 hours until it is completely thawed, repeat this step 3 times or more, and get PVA cryogel;

[0036] 3) Stretch the PVA cryogel obtained in step 2) to a certain length, immerse in a cross-linking agent to cross-link for a certain period of time, wash away impurities with deionized water after completion, and dry under controllable temperature and humidity to obtain a single layer PVA hydrogel with oriented structure;

[0037] 4) Attach two pieces of PVA hydrogels with a single-layer orientation s...

Embodiment 1

[0042] 1) Preparation of the inner layer: Polyvinyl alcohol with a molecular weight of 2,000,000 Da is configured into an aqueous solution with a mass fraction of 10%, and 1% cellulose is added therein as a reinforcing material to obtain a precursor solution; the precursor solution is poured into a flat mold, Freeze at -20°C after self-leveling for 3 hours, take it out and rewarm at room temperature for 3 hours, repeat this step 3 times to obtain PVA cryogel; stretch the gel to 2 times its original length and Fix and soak in 3% glutaraldehyde solution for 10 minutes to obtain an aligned PVA hydrogel.

[0043]2) Preparation of the outer layer: configure polyvinyl alcohol with a molecular weight of 2,000,000Da into an aqueous solution with a mass fraction of 10%, and add 1% cellulose and 1% sodium alginate to obtain a precursor solution; pour the precursor solution Put it into a flat plate mold, freeze it at -20°C after it is self-leveling, continue for 3 hours, take it out and ...

Embodiment 2

[0046] The difference from Example 1 is that the molecular weight of polyvinyl alcohol used in step 1) and step 2) of this example is 1,000,000 Da, and the mass percentage of its solution is 15%.

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Abstract

The invention discloses a penis albuginea repair patch with a double-layer structure and a preparation method of the penis albuginea repair patch, the albuginea repair patch is composed of polyvinyl alcohol, a reinforcing material, bioactive polysaccharide and a cross-linking agent, and comprises an inner layer close to a cavernous body side and an outer layer far away from the cavernous body side. Wherein both the inner layer and the outer layer take polyvinyl alcohol as a base material, a fibrous reinforcing material is uniformly dispersed in the base material, and the hydrogel patch with an oriented structure and mechanical adaptability is obtained through a circulating freezing-pre-stretching-crosslinking method; bioactive polysaccharides are introduced into the outer layer through blending modification, so that the albuginea repair patch is endowed with a suitable hemostatic function and biocompatibility. The penis albuginea repairing patch with the double-layer structure is good in biological safety, wide in raw material source and capable of being processed in a customized mode and has mechanical and structural characteristics matched with tissue. The traditional Chinese medicine composition can be used for treating albuginea injury caused by diseases such as penile induration, trauma and penile cancer, and can promote recovery of reproductive functions of patients.

Description

technical field [0001] The invention relates to the technical field of biomedical materials and tissue engineering, in particular to a double-layer structure penis albuginea repair patch and a preparation method thereof. Background technique [0002] The penis is an important reproductive and urinary organ for men, but various diseases and traumas may cause damage to the penis. From a biomechanical point of view, the penis is a typical hydrostatic skeletal system, in which the blood-rich spongy body provides support pressure, while the albuginea acts as an external support and plays an indispensable role in maintaining the rigidity of the erect penis role. Damage to the albuginea can lead to a series of problems such as penile curvature and erection pain. In severe cases, it may even be impossible to complete sexual intercourse, which has a huge impact on the patient's physical and mental health. [0003] Ultimately, surgery is required to cut, fold, and suture damaged str...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/24A61L27/22A61L27/16A61L27/50A61L27/52
CPCA61L27/20A61L27/24A61L27/227A61L27/16A61L27/50A61L27/52A61L2430/34C08L29/04
Inventor 施雪涛柴牧原
Owner SOUTH CHINA UNIV OF TECH
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