Drug sensitivity prediction method and device based on multi-omics similarity guidance

Abstract

The invention discloses a drug sensitivity prediction method and device based on multi-omics similarity guidance, and the method comprises the steps: a cell line diagram constructed based on multi-omics data of a cell line can fully integrate four types of multi-omics information of genomics data, transcriptomics data, proteomics data and metabonomics data of an individual cell line; compared with an existing cell line characterization mode, more kinds of omics information can be contained, and meanwhile the potential relation between products expressed by the cell line in the multi-omics level is fully considered; on the basis, a drug sensitivity prediction model for predicting the drug sensitivity based on the cell line diagram adopts a multi-omics similarity guiding mode, multi-omics similarity among individuals can be fully considered while multi-omics information of individual specificity is efficiently extracted, huge biological priori knowledge can be provided, and the drug sensitivity prediction model can be used for predicting the drug sensitivity based on the cell line diagram. Therefore, more accurate drug sensitivity prediction is realized.

Description

technical field [0001] The invention belongs to the technical field of drug sensitivity detection and evaluation, and in particular relates to a drug sensitivity prediction method and device guided by multi-omics similarity. Background technique [0002] Drug sensitivity prediction is a great challenge in precision cancer therapy. Many researchers have made a lot of efforts and contributions on this issue, trying to use individual genomics data to make personalized diagnosis and medication recommendations for patients. However, existing research still faces an important problem, how to make full use of the complex and diverse multi-omics data of each individual, and make full use of the similarities and differences between individuals to achieve more efficient feature extraction, so as to achieve more accurate drug efficacy prediction and medication recommendation. [0003] With the deepening of genomics research, some public data sets have been more and more widely used i...

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Problems solved by technology

[0007] In view of the above, the purpose of the present invention is to provide a drug sensitivity prediction method and device based on multi-omics similarity guidance to solve the problem of similar drug sensitivity reactions due to ignoring individual multi-omics data and similarities between individuals. The problem of poor drug sensitivity prediction accuracy due to prior knowledge

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