Veterinary composition for preventing and/or treating cryptosporidiosis

A technology of sporidiosis and composition, applied in the treatment of cryptosporidiosis in non-human mammals, treatment of non-human mammals, veterinary compositions for the treatment of cryptosporidiosis in non-human mammals, antibiotic compositions , Paromomycin or its pharmaceutically acceptable salt, Cryptosporidiosis, eradication or elimination of Cryptosporidium parvum, can solve problems such as damage to livestock nutritional effects and growth, can not completely eradicate the parasite

Pending Publication Date: 2022-03-29
法国诗华大药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Use of certain medications can reduce oocyst shedding and clinical signs, but do not completely eradicate the parasite
In addition, parasitic infections are often associated with significant weight loss, which impairs the nutritional performance and growth of livestock

Method used

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  • Veterinary composition for preventing and/or treating cryptosporidiosis
  • Veterinary composition for preventing and/or treating cryptosporidiosis
  • Veterinary composition for preventing and/or treating cryptosporidiosis

Examples

Experimental program
Comparison scheme
Effect test

example

[0048] Materials and Methods

[0049] combination

[0050] The composition used in this study was an oral solution containing 200 mg / mL paromomycin sulfate (equivalent to 140 mg / mL paromomycin). Different doses of paromomycin sulfate of 75, 100 and 150 mg / kg were obtained from this 200 mg / mL paromomycin sulfate oral solution.

[0051] treat

[0052] 35 2- to 4-day-old calves were inoculated with approximately 10 6 sporulated oocysts of Cryptosporidium parvum. The calves were then divided into the following 4 groups and treated at Dt0 (Day 0) under the following conditions:

[0053]- 9 calves, untreated (control group);

[0054] - 9 calves treated with 75 mg / kg / day of paromomycin sulfate for 5 days (group 75);

[0055] - 9 calves treated with 100 mg / kg / day paromomycin sulfate for 5 days (100 groups); and

[0056] - 9 calves treated with 150 mg / kg / day paromomycin sulphate for 5 days (group 150).

[0057] result

[0058] 1. Clinical signs

[0059] Diarrhea (st...

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Abstract

The present invention relates to a veterinary composition comprising paromomycin or a pharmaceutically acceptable salt thereof for use in the prevention and / or treatment of cryptosporidiosis in a non-human mammal wherein the composition is administered to the non-human mammal at a paromomycin dosage of 80 to 140 mg / kg / day for 3 to 6 days.

Description

[0001] purpose of invention [0002] The present invention relates to the field of veterinary medicine, and more particularly to the use of an antibiotic composition for the treatment of cryptosporidiosis in non-human mammals, preferably young cattle. Background technique [0003] Cryptosporidiosis is a zoonotic worldwide disease caused by protozoa of the genus Cryptosporidium, which is of great medical and economic importance. In fact, Cryptosporidium is a widely distributed parasite with a strong ability to reproduce and spread. It primarily contaminates mammals, reptiles, birds and fish through direct contact with infected water, animals or food. Cryptosporidium parvum is the most prevalent zoonotic species and is responsible for most infections in mammals, including ruminants, as well as most waterborne pollution. Ruminants are a major source of human pollution. [0004] Thus, cryptosporidiosis is a major global public health challenge. It is estimated that 30-50% of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61P33/02
CPCA61K31/7036A61K9/0053A61P33/02A61P33/00A61K9/08A61K9/0095Y02A50/30
Inventor B·贝舍C·希门尼斯
Owner 法国诗华大药厂
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