Regenerative electrode and preparation method thereof

A technology of electrodes and working electrodes, which is applied in the field of biosensors, can solve problems such as silver/silver chloride shedding, easy polarization, and gold electrode damage, and achieve the effects of simple preparation, low cost, and easy operation

Pending Publication Date: 2022-04-15
INST OF CHEM ENG GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no related technology to disclose how to remove the Nafion embedded film
2. Materials such as chitosan, carbon nanotubes, carbon aerogels, and Prussian blue have strong adhesion and must be removed without damaging the gold electrode. When using materials such as carbon nanotubes, carbon aerogels, and Prussian blue, it is inevitable to cause damage to the gold electrode
3. The use of ultrasonic cleaning will cause the silver / silver chloride as a reference electrode to fall off
4. Cleaning the electrode with hydrochloric acid, sulfuric acid, etc. will easily cause the electrode to be corroded, and polarization will easily occur when using cyclic voltammetry to detect
Strong hydrochloric acid and sulfuric acid solutions have certain operational safety risks during the use and preparation of reagents

Method used

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  • Regenerative electrode and preparation method thereof
  • Regenerative electrode and preparation method thereof
  • Regenerative electrode and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0048] The following is an example of a flexible gold three-electrode glucose sensor with a working electrode diameter of 4 mm and an overall width of 10 mm. figure 1 As shown in A1, the flexible gold three-electrode glucose sensor comprises a flexible PET base plated with gold three electrodes, including as the working electrode ( figure 1 Circular area in ) and a gold electrode as a counter electrode, and silver / silver chloride as a reference electrode, where the working electrode is covered with a mixture of chitosan, carbon nanotubes, carbon aerogel, Prussian blue and Nafion .

[0049] The regeneration treatment method of the invalid flexible gold three-electrode glucose sensor comprises the following steps:

[0050] (1) Prepare 2mol / L sodium hydroxide solution, then mix 1 part of 2mol / L sodium hydroxide solution and 1 part of absolute ethanol to prepare a flexible gold three-electrode cleaner. Add 40 μL of flexible gold three-electrode cleaner dropwise on the gold three...

Embodiment 2

[0056] In this example, the failed flexible gold three-electrode glucose sensor is regenerated, and the structure of the failed flexible gold three-electrode glucose sensor is the same as that in Example 1, and the physical photos are as follows image 3 Shown in A1, the regeneration treatment method comprises the following steps:

[0057] (1) prepare the sodium hydroxide solution of 2mol / L, then mix 2 parts of 2mol / L sodium hydroxide solution and 1 part of dehydrated alcohol to obtain a clear and transparent flexible gold three-electrode cleaner, such as Figure 4 As shown in A. Add 30 μL of flexible gold three-electrode cleaner dropwise on the gold three-electrode, stir with a plastic rod with a diameter of 1mm, dissolve and remove the Nafion film used to encapsulate the electrode, chitosan, carbon nanotubes, and carbon adhering to the surface of the working electrode. Airgel, Prussian blue and other materials such as image 3 Shown in A2. Then use ultra-pure water to rin...

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Abstract

The invention belongs to the technical field of biosensors, and particularly discloses a regeneration electrode and a preparation method thereof. The preparation method of the regenerated electrode comprises the following steps: cleaning a working electrode of a failure sensor by using a cleaning agent to obtain an electrode 1; the cleaning agent contains inorganic base and alcohol; the failure sensor comprises a working electrode, and the working electrode is covered with a mixture of at least one of chitosan, carbon nanotubes, carbon aerogel and Prussian blue and a binder. And performing cyclic voltammetry scanning on the electrode 1 in a KCl / PBS buffer solution and an inorganic alkali solution in sequence to obtain the regenerated electrode. According to the method, materials such as a Nafion film, chitosan, a carbon nano tube, carbon aerogel and Prussian blue attached to the failure sensor can be effectively removed, hydrochloric acid, sulfuric acid and other highly corrosive dangerous reagents do not need to be used, and the electrode can be recycled and used for preparing the sensor again.

Description

technical field [0001] The invention relates to the technical field of biosensors, in particular to a regenerative electrode and a preparation method thereof. Background technique [0002] The wearable flexible glucose sensor can realize the non-invasive detection of blood glucose, so that the blood glucose tester can avoid the pain of needle stick. Gold has the advantages of strong stability, high conductivity, and good biocompatibility. Combined with polyethylene terephthalate PET and silver / silver chloride, gold electrodes can be used as working electrodes and reference electrodes. Silver / silver chloride is a flexible gold triple electrode as the reference electrode. Further use of Prussian blue, chitosan, glucose oxidase, carbon nanotubes, carbon aerogel and other materials to modify the flexible gold three-electrode can make a flexible gold three-electrode glucose sensor for non-invasive detection of blood sugar. For example, the related technology discloses a prepara...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/38G01N27/327
CPCY02E60/50
Inventor 李彬曾炜石超生张静斐
Owner INST OF CHEM ENG GUANGDONG ACAD OF SCI
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