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Stable marbofloxacin injection solution

A technology of marbofloxacin and solution, applied in the field of anti-infective injection solution containing marbofloxacin, can solve the problems of animal tolerance, difficulty in injection and the like

Pending Publication Date: 2022-05-27
JIANGSU ROTAM CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This situation will lead to animal tolerability problems and make injections difficult

Method used

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  • Stable marbofloxacin injection solution
  • Stable marbofloxacin injection solution
  • Stable marbofloxacin injection solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] The above-mentioned marbofloxacin, nicotinamide, benzyl alcohol, and dibutylhydroxytoluene were respectively added to the purified water by weight, and the pH value of the concentrate was measured to be 5.7, and the concentrate was evenly stirred to obtain a prepared concentrate.

Embodiment 2

[0030]

[0031] The above-mentioned marbofloxacin, nicotinamide, benzyl alcohol, and dibutylhydroxytoluene were respectively added to the purified water by weight, and the pH value of the concentrate was measured to be 5.7, and the concentrate was evenly stirred to obtain a prepared concentrate.

Embodiment 3

[0033]

[0034] The above-mentioned marbofloxacin, nicotinamide, magnesium chloride hexahydrate, benzyl alcohol, and dibutylhydroxytoluene were respectively added to purified water by weight, and the pH value of the concentrate was measured to be 5.7, and the mixture was uniformly stirred to obtain a prepared concentrate.

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PUM

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Abstract

The invention relates to a stable marbofloxacin injection solution, in particular to an antibacterial solution which at least contains marbofloxacin or at least one pharmaceutically acceptable salt of marbofloxacin and at least one solubilizer in a pharmaceutically acceptable carrier.

Description

technical field [0001] The technical field of the present invention relates to an injection solution for treating or preventing infection in animals, and more particularly to an anti-infective injection solution containing marbofloxacin, and the injection solution can exist in the form of a high-concentration solution. Background technique [0002] For the treatment or prevention of pigs, horses, cattle, sheep and other economic animals, the commonly used treatment method is injection administration, especially for anti-infective drugs for the purpose of treatment, prevention and quasi-prevention, injection administration is relatively common. [0003] Products for parenteral administration need to take into account the dose, frequency of administration, and animal tolerance. This is also a factor that affects the mode of administration. Due to the larger doses administered to animals with larger body weight, the low-concentration drug products require large doses and / or mu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/5395A61K47/22A61P31/00
CPCA61K31/5395A61K9/08A61K9/0019A61K47/22A61P31/00
Inventor 詹姆斯·T·布里斯托
Owner JIANGSU ROTAM CHEM
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