Application of 5-hydroxytryptophan in preparation of health care product or medicine for improving female physiological cycle disorder caused by plateau hypoxia

A high-altitude low-oxygen, hydroxytryptophan technology, applied in the biological field, can solve problems such as physiological cycle disorders in female rats

Pending Publication Date: 2022-06-03
INST OF ENVIRONMENTAL MEDICINE & OCCUPATIONAL MEDICINE ACAD OF MILITARY MEDICINE ACAD OF MILITARY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Our previous research found that high-altitude hypoxia exposure caused physiological cycle disorders in female rats, accompanied by abnormal secretion of luteinizing hormone. Whether 5-hydroxytryptophan can improve the anti-hypoxic ability of females and improve the physiological cycle disorders of high-altitude hypoxic female rats still remains to be seen. No report

Method used

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  • Application of 5-hydroxytryptophan in preparation of health care product or medicine for improving female physiological cycle disorder caused by plateau hypoxia
  • Application of 5-hydroxytryptophan in preparation of health care product or medicine for improving female physiological cycle disorder caused by plateau hypoxia
  • Application of 5-hydroxytryptophan in preparation of health care product or medicine for improving female physiological cycle disorder caused by plateau hypoxia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 The effect of 5-hydroxytryptophan on the survival time of female mice under normal pressure airtight hypoxia

[0017] 1. Experimental animals

[0018] Twenty SPF grade Kunming female mice, weighing 18-20 g, were purchased from Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd.

[0019] 2. Experimental Drugs

[0020] (1) 0.5% sodium carboxymethyl cellulose solution: take 5 g of sodium carboxymethyl cellulose powder, add ultrapure water to 1000 ml, and stir with a magnetic stirrer to accelerate dissolution.

[0021] (2) 5-Hydroxytryptophan solution: Weigh 5-Hydroxytryptophan (Swanson) according to the body weight of the mice and dissolve it in 0.5% sodium carboxymethylcellulose solution to prepare a 5-Hydroxytryptophan solution .

[0022] 3. Grouping and administration of experimental animals

[0023] Twenty 18-20 g female mice were adaptively housed for 7 days. After 7 days, the mice were randomly divided into groups, 10 mice in each group, the b...

Embodiment 2

[0028] Example 2 The regulatory effect of 5-hydroxytryptophan on the physiological cycle of hypoxia-exposed female rats

[0029] 1. Experimental animals

[0030] Thirty-six SPF-grade female SD rats, weighing 180-200 g, were provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd.

[0031] 2. Experimental Drugs

[0032] (1) 0.5% sodium carboxymethyl cellulose solution: take 5 g of sodium carboxymethyl cellulose powder, add ultrapure water to 1000 ml, and stir with a magnetic stirrer to accelerate dissolution.

[0033] (2) 5-Hydroxytryptophan solution: Weigh 5-Hydroxytryptophan (Swanson) according to the body weight of the mice and dissolve it in 0.5% sodium carboxymethylcellulose solution to prepare a 5-Hydroxytryptophan solution .

[0034] 3. Grouping and administration of experimental animals

[0035] Female SD rats were reared adaptively for 7 days, and then randomly divided into blank control group (Control, 0.5% carboxymethyl cellulose sodium solution) ...

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Abstract

The invention discloses an application of 5-hydroxytryptophan in preparation of a health care product or a medicine for improving female physiological cycle disorder caused by altitude hypoxia, and experiments prove that the 5-hydroxytryptophan can obviously prolong the closed hypoxia survival time of a female organism and can obviously improve the female physiological cycle disorder caused by low-pressure hypoxia exposure.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to the application of 5-hydroxytryptophan in the preparation of health-care products or medicines for improving female physiological cycle disorders caused by high altitude hypoxia. Background technique [0002] At present, there are more than 500 million people living in the plateau and alpine areas in the world, and my country's plateau area is vast, and the area above 3,000m above sea level accounts for about 1 / 6 of the country's total area. The country with the largest population living in the highlands and high mountains. The plateau is a special environment with many unfavorable factors for the human body, such as low air pressure, low partial pressure of oxygen, cold, dryness and strong sunlight radiation, etc. Among them, low oxygen is the biggest threat, and the partial pressure of oxygen inhaled in the plateau at an altitude of 4600 meters is almost Only half of the sea level ...

Claims

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Application Information

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IPC IPC(8): A61K31/405A61P15/00A23L33/175
CPCA61K31/405A61P15/00A23L33/175A23V2002/00A23V2200/30A23V2250/065
Inventor 刘伟丽陈照立蒲玲玲徐洪宝王新兴王天辉李冉王紫瑈艾崇毅
Owner INST OF ENVIRONMENTAL MEDICINE & OCCUPATIONAL MEDICINE ACAD OF MILITARY MEDICINE ACAD OF MILITARY SCI
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