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Novel nano sustained-release drug-loaded material for inhibiting antibody-mediated rejection reaction in targeted immune hair growth center, preparation method and application of novel nano sustained-release drug-loaded material

A technology for inhibiting antibodies and rejection reactions, applied in the field of new nano-sustained-release drug-carrying materials, can solve the problems of systemic drug damage, lack of lesion characteristic targeting, lack of controllable release function, etc., to achieve small side effects, neurotoxicity and renal Less toxic, less toxic effect

Pending Publication Date: 2022-06-03
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the current nano-scale drug carriers have some shortcomings, such as lack of lesion characteristic targeting, lack of controllable release function, and peripheral and systemic drug damage, etc. Therefore, it is necessary to provide a new type of nano drug-loading material

Method used

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  • Novel nano sustained-release drug-loaded material for inhibiting antibody-mediated rejection reaction in targeted immune hair growth center, preparation method and application of novel nano sustained-release drug-loaded material
  • Novel nano sustained-release drug-loaded material for inhibiting antibody-mediated rejection reaction in targeted immune hair growth center, preparation method and application of novel nano sustained-release drug-loaded material
  • Novel nano sustained-release drug-loaded material for inhibiting antibody-mediated rejection reaction in targeted immune hair growth center, preparation method and application of novel nano sustained-release drug-loaded material

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Embodiment Construction

[0029]The technical solutions of the present invention will be described in further detail below with reference to the accompanying drawings. It should be noted that the specific embodiments are only detailed descriptions of the present invention and should not be regarded as limitations of the present invention, wherein 1M=1mol / L.

[0030] 1. Synthesis process

[0031] 1. Preparation of Mesoporous Silica Nanospheres

[0032] Using cationic surfactant CTAC (hexadecyltrimethylammonium chloride) as template, TEOS (ethyl orthosilicate) as silica source, TEA (triethylamine) as catalyst, cyclohexene as emulsifier , MSNs were continuously grown by a one-pot two-phase stratification method.

[0033] The specific synthesis is as follows: firstly, 20-40ml (25wt%) CTAC aqueous solution and 0.18g TEA were added to 36mL water, and the mixture was slowly stirred at 60°C for 1 hour. Then 20mL (10v / v%) TEOS cyclohexene solution was added to the above mixture of water, CTAC and TEA, and the...

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Abstract

The invention discloses a novel nano sustained-release drug-loaded material for inhibiting antibody-mediated rejection reaction in a targeted immune hair growth center, a preparation method and application. The novel nano drug-loaded material has targeting property, can slowly release drugs, can be used for treating inflammatory infiltration of transplanted organs, and is low in toxicity (low in neurotoxicity and renal toxicity) and small in side effect.

Description

technical field [0001] The invention specifically relates to a novel nanometer sustained-release drug-carrying material for targeting immune germinal centers to inhibit antibody-mediated rejection, a preparation method and an application. Background technique [0002] Nanoscale drug carriers (Nanoscale Drug Carriers) are subparticulate drug carrier delivery systems that belong to the nanoscale and microscopic category. Encapsulating drugs in sub-particles can adjust the speed of drug release, increase the permeability of biofilms, change the distribution in the body, and improve bioavailability. Nanoparticles, also known as nanoparticles, are solid colloidal particles with a size between 10 and 1000 nm. They are generally composed of natural macromolecules or synthetic macromolecules and can be used as carriers for conducting or delivering drugs. [0003] However, the current nanoscale drug carriers have some shortcomings, such as the lack of characteristic targeting of les...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/61A61K47/54A61K39/395A61P29/00A61P37/06B82Y5/00B82Y40/00A61K31/436
CPCA61K47/6923A61K47/61A61K47/543A61K39/3955A61P37/06A61P29/00B82Y5/00B82Y40/00A61K31/436
Inventor 沈佳张宏博严芃芃刘昌黄洪锋王仁定
Owner ZHEJIANG UNIV
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