Protein structure prediction

A protein and structural attribute technology, applied in the analysis of two-dimensional or three-dimensional molecular structure, neural architecture, instruments, etc., can solve the problems of small number of proteins and time-consuming

Pending Publication Date: 2022-07-01
MICROSOFT TECH LICENSING LLC
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Problems solved by technology

However, determining the structure of proteins experimentally is very time-consuming, and the number of proteins whose structures are experimentally determined is small

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  • Protein structure prediction
  • Protein structure prediction
  • Protein structure prediction

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Embodiment Construction

[0012] The present disclosure will now be discussed with reference to several example implementations. It should be understood that these implementations are discussed only to enable those of ordinary skill in the art to better understand and thereby implement the present disclosure, and are not intended to imply any limitation on the scope of the present disclosure.

[0013] As used herein, the term "including" and variations thereof are to be read as open-ended terms meaning "including, but not limited to." The term "based on" is to be read as "based at least in part on". The terms "an implementation" and "an implementation" are to be read as "at least one implementation." The term "another implementation" is to be read as "at least one other implementation." The terms "first", "second", etc. may refer to different or the same objects. Other explicit and implicit definitions may also be included below.

[0014] As used herein, a "neural network" is capable of processing ...

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Abstract

According to the implementation of the invention, a scheme for predicting the protein structure is provided. In the scheme, a plurality of fragments are determined for each residue position in a plurality of residue positions of a target protein from a fragment library for the target protein. Each fragment comprises a plurality of amino acid residues. Then, for each residue position, a feature representation of the structure of the plurality of fragments is generated. Next, a prediction of at least one of a structure and a structural property of the target protein is determined based on the respective feature representations generated for the plurality of residue locations. According to the scheme, information used in protein structure prediction can be supplemented and perfected by using the structure information of the fragment library, so that the accuracy of protein structure prediction is improved.

Description

Background technique [0001] Proteins are biomolecules or macromolecules composed of long chains of amino acid residues. Proteins perform many important life activities in living organisms, and the functions of proteins are mainly determined by their three-dimensional (3D) structures. Knowing the structure of proteins is very important to the fields of medicine and biotechnology. For example, if a protein plays a key role in a disease, drug molecules can be designed based on the protein's structure to treat the disease. However, determining the structure of a protein by experimental means is very time-consuming, and the number of proteins whose structure is experimentally determined is very small. Therefore, low-cost, high-yield protein structure prediction has become an important means to study protein structure. SUMMARY OF THE INVENTION [0002] According to the realization of the present disclosure, a scheme for protein structure prediction is proposed. In this protoco...

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Application Information

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IPC IPC(8): G16B35/20G16B25/00
CPCG16B35/20G16B25/00G16B15/20G06N3/048G06N3/045
Inventor 王童邵斌刘铁岩
Owner MICROSOFT TECH LICENSING LLC
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