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MiRNA marker for Kawasaki disease coronary artery injury and application thereof

A technique for coronary artery disease and Kawasaki disease, applied in the field of gene markers, can solve the problems of lack of MiR-26a and restriction of early diagnosis and treatment of KD

Pending Publication Date: 2022-07-08
河北省儿童医院
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] In the prior art, there are few publications on miRNA markers related to Kawasaki disease, and there are few reports on the regulatory role of MiR-26a in KD, which restricts the early diagnosis and treatment of KD

Method used

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  • MiRNA marker for Kawasaki disease coronary artery injury and application thereof
  • MiRNA marker for Kawasaki disease coronary artery injury and application thereof
  • MiRNA marker for Kawasaki disease coronary artery injury and application thereof

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Experimental program
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Embodiment

[0026] Twenty children diagnosed with KD in the Department of Cardiology, Hebei Children's Hospital from June 2020 to September 2021 were selected and included in the KD group. Scientific Statements for Health Professionals" [1]. Another 20 healthy children from the Health Department of Hebei Children's Hospital were selected as the control group. In the KD group, there were 11 males and 9 females with an average age of 2.4±1.1 years; in the control group, there were 10 males and 10 females with an average age of 3.1±1.4 years; there was no significant difference in gender and age between the two groups ( P>0.05). The blood collection time of the KD children was before the administration of gamma globulin after the diagnosis of KD; the blood collection time of the children in the control group was during the physical examination in the Children's Health Department of our hospital. 3 ml of peripheral blood samples were collected from two groups of children, centrifuged at 200...

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PUM

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Abstract

The invention discloses a miRNA (micro Ribonucleic Acid) marker for Kawasaki disease coronary artery injury, which is miRNA-26a-5p and can be used as a marker for predicting formation of coronary artery tumor. As a potential therapeutic target of KD and an auxiliary index for early prediction of acute KD diagnosis; the invention provides a diagnostic kit for predicting formation of kawasaki disease coronary artery tumor. The kit is a miRNA-26a-5p detection kit. According to the invention, the miRNA-26a-5p is used as a potential therapeutic target of KD and is used as an auxiliary indicator for early prediction of acute KD diagnosis, and detection of the miRNA-26a-5p is used as a judgment basis.

Description

technical field [0001] The invention relates to a miRNA marker for coronary artery damage in Kawasaki disease and its application, and relates to the technical field of gene markers. Background technique [0002] Kawasaki disease (KD) is a febrile disease with vasculitis as the main lesion. It mostly occurs in children under the age of 5. It mainly affects the small and medium arteries of various systems of the body, as well as the skin, mucous membranes, and lymph nodes. Mucocutaneous lymph node syndrome. The main features of KD are acute fever, hyperactivation of the immune system, and damaging vasculitis. Coronary Artery Lesions (CAL) is a serious complication of KD, which may further develop into coronary artery aneurysm, coronary stenosis, etc. It is the primary cause of acquired heart disease in children and the main cause of myocardial infarction in adolescents. In recent years, the incidence of KD in my country has been increasing year by year, but the pathogenesis...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/178C12Q2600/158
Inventor 张英谦郝京霞李博赵紫薇王莹雪张会敏武霏王文露曹亚丽
Owner 河北省儿童医院
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