Methods of treating lichen planus using interleukin-17 (IL-17) antagonists

Abstract

The present disclosure relates to methods of treating lichen planus (e.g., hair lichen planus, mucosal lichen planus, skin lichen planus) using an interleukin (IL)-17 antagonist, such as secukinumab. Also disclosed herein are IL-17 antagonists, e.g., IL-17 antibodies, e.g., secukinumab, for use in the treatment of patients suffering from lichen planus (e.g., hair lichen planus, mucosal lichen planus, skin lichen planus), as well as medicaments, dosing regimens, pharmaceutical formulations, dosage forms, and kits for use in the disclosed uses and methods.

Description

technical field [0001] The present disclosure relates to methods of treating lichen planus (LP) and lichen planus pilaris (LPP) using IL-17 antagonists (eg, IL-17 antibodies, such as secukinumab). Background technique [0002] Lichen planus (LP) is a chronic, inflammatory disorder that can involve the skin, oral or genital mucosa, conjunctiva, and nails (sometimes concomitantly), while maintaining a consistent histological phenotype. The disease presents as multiple papules on the skin (cutaneous lichen planus (CLP)), which can be localized or generalized, and are often very itchy and painful. Mucosal disease (mucosal lichen planus (MLP)) can consist of asymptomatic plaques or very painful erosive lesions and ulcers. Lichen planus pilaris (LPP), a follicular form of lichen planus, is a rare inflammatory lymphocyte-mediated disorder that selectively affects hair follicles. LPP can lead to hair follicle destruction and thus scarring alopecia (Assouly et al. (2009) Semin Cuta...

AI Technical Summary

Problems solved by technology

Systemic immunosuppressants (eg, corticosteroids, cyclosporine, methotrexate, and azathioprine), as well as immunomodulators (eg, acitretin), help reduce disease symptoms but can lead to significant side effects

Furthermore, 30%–50% of patients are refractory to current LP therapies and experience higher disease burden due to lack of clinical control, as well as significant psychological discomfort and deficits in social functioning, resulting in severely impaired quality of life

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