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Biologically catalytic process of preparing konjak glucomannan in no-solvent system

A technology of konjac glucomannan and glucomannan ester, which is applied in the field of biocatalysis and biosynthesis, can solve the problems of by-products and difficult separation of products, poor selectivity, environmental pollution, etc. Mild conditions and environmentally friendly effects

Inactive Publication Date: 2006-12-06
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemical synthesis of glucomannan esters requires high energy consumption, poor selectivity, easy to produce by-products and difficult separation of products; and because a large amount of organic solvents and catalysts are used in the reaction process, on the one hand, it will bring serious environmental pollution problems, and on the other hand On the one hand, some toxic chemical substances often remain in the product, which makes it difficult to apply in cosmetics, food and pharmaceutical industries

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Put 0.5g konjac glucomannan with a water activity of 0.11, 20mg lipase (10,000U / g) derived from Candida antarctica (Candida antarctica) and 6ml vinyl acetate into a stoppered Erlenmeyer flask, place Oscillate in a constant temperature oscillator in a water bath at 30°C and 100 rpm. After reacting for 6 hours, filter to remove lipase, centrifuge at 4000 rpm for 5 minutes, and remove the supernatant. The obtained precipitate is fully washed with absolute ethanol, centrifuged and The precipitate was vacuum-dried (45° C., 0.08 MPa) to obtain konjac glucomannan acetate with a degree of substitution of 0.38.

Embodiment 2

[0019] 0.5 g of konjac glucomannan, 100 mg of lipase (10,000 U / g) derived from Candida antarctica (Candida antarctica) and 6 ml of ethyl butyrate were put into a stoppered Erlenmeyer flask with a water activity of 0.33, Vibrate in a constant temperature oscillator in a water bath at 60°C and 200rpm. After reacting for 24 hours, filter to remove lipase, centrifuge at 4000rpm for 5 minutes and remove the supernatant. The obtained precipitate is fully washed with absolute ethanol, and after centrifugation Vacuum-dry the precipitate (45°C, 0.08MPa) to obtain konjac glucomannan butyrate with a substitution degree of 0.25.

Embodiment 3

[0021] 0.5 g of konjac glucomannan, 400 mg of lipase (10,000 U / g) derived from Candida antarctica (Candida antarctica) and 6 ml of vinyl laurate were put into a stoppered Erlenmeyer flask with a water activity of 0.54, Vibrate in a water bath constant temperature oscillator at 50°C and 200rpm. After reacting for 6 hours, filter to remove lipase, centrifuge at 4000rpm for 5 minutes and remove the supernatant. The obtained precipitate is fully washed with absolute ethanol, and after centrifugation Vacuum-dry the precipitate (45°C, 0.08MPa) to obtain konjac glucomannan laurate with a substitution degree of 0.65.

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Abstract

The present invention relates to biologically catalytic process of preparing konjak glucomannan ester in no-solvent system. In no-solvent system with fatty acid ester as acyl radical donor and lipase as catalyst, konjak glucomannan is acidated to produce konjak glucomannan ester. The present invention has the advantages of mild reaction condition, environment friendship, selectivity and controllability of reaction, simple reaction process and easy separation of reaction product from the reaction mixture system.

Description

technical field [0001] The invention belongs to the field of biocatalysis and biosynthesis, and relates to a method for preparing konjac glucomannan ester by biocatalysis in a solvent-free system. Background technique [0002] Konjac glucomannan (KGM) is a polysaccharide derived from the plant konjac, which is very rich in my country and is a renewable resource. It has excellent biocompatibility, biodegradability and unique physicochemical properties. Research has found that: KGM and its derivatives have important application value and broad application prospects in the fields of medicine and preventive medicine, chemical industry, textile, oil drilling, environmental protection, new materials, and bioengineering. The acylated products of KGM can have different physicochemical properties and biological activities according to their structures, and can be used as green chemicals (such as surfactants, antibacterial agents, etc.), as well as surgical agents with biocompatibili...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/02C12P19/08
Inventor 宗敏华陈志刚丁锐李光吉
Owner SOUTH CHINA UNIV OF TECH
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