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Method for treating hair-dropping using thyromimetic compound

A drug, technology of use, applied in the field of treatment of hair loss with thyromimetic compounds, can solve the problems of cardiotoxicity, adverse side effects, unrealistic hair, etc.

Inactive Publication Date: 2007-05-09
PFIZER PRODS ETAT DE CONNECTICUT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Thus, thyroid hormones are known to have a positive effect on hair growth; however, T 3 and / or T 4 Dosing to treat hair is impractical as these thyroid hormones are known to cause adverse side effects such as inducing overt cardiotoxicity or adversely affecting bone mineral density and lean body mass

Method used

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  • Method for treating hair-dropping using thyromimetic compound
  • Method for treating hair-dropping using thyromimetic compound
  • Method for treating hair-dropping using thyromimetic compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A

[0316] components

Embodiment B

[0318] According to the method described in Dowton et al. "Influence of Liposomal Composition on Topical Delivery of Encapsulated Cyclosporin A: I. An in vitro Study Using Hairless Mouse Skin", S.T.P.Pharma Sciences, Vol.3, Pp.404-507 (1993), with The active ingredient was substituted for cyclosporin and Novasome 1 was used for the non-ionic liposome formulation to prepare a topical composition.

[0319] A male subject suffering from alopecia areata was treated daily with the composition described above. Specifically, the composition described above was administered topically to the subject for 6 days.

Embodiment C

[0321] components

[0322] A human subject suffering from male pattern baldness is treated by the method of the invention. Specifically, the above-mentioned shampoo was applied daily to the subjects for 12 weeks.

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PUM

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Abstract

The present invention provides methods and compositions for treating hair loss (including preventing and / or reversing hair loss and promoting hair growth) in mammals such as humans, companion animals and livestock using certain thyroid mimetic compounds.

Description

field of invention [0001] The present invention provides a method and composition for treating hair loss (including arresting and / or reversing hair loss and promoting hair growth) in mammals, such as humans, companion animals and livestock, using certain thyromimetic compounds described below. Background of the invention [0002] Hair loss is a common problem that occurs through natural processes or is often chemically promoted by the use of certain medications aimed at alleviating medical conditions such as cancer. This hair loss is usually accompanied by the fact that the hair does not regrow, which results in partial or total baldness. [0003] As is well known in the art, hair growth occurs in active cycles comprising alternating phases of growth and rest. This cycle is usually divided into three main phases known as regeneration, involution and quiescence. The genital phase is the growth phase of the cycle, characterized by the infiltration of the hair follicle deep i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A61K31/53A61K31/41A61P17/14C07D249/12A61K8/00A61K8/42A61K8/49A61K8/58A61K9/06A61K9/08A61K9/10A61K9/12A61K31/404A61K31/4196A61K31/4245A61K31/426A61K31/506A61K31/568A61K31/57A61Q5/00A61Q5/02A61Q7/00C07D253/06C07D271/06C07D277/20C07D277/34C07D401/12C07D491/107
CPCA61K8/494A61K8/49A61Q7/00A61K31/53A61K8/4966A61K31/404A61K8/42A61P17/14A61P7/06A61K8/58
Inventor 江苑青彼得·科尼利厄斯尼尔·S·多尔蒂罗伯特·L·道
Owner PFIZER PRODS ETAT DE CONNECTICUT