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Phytomics: A genomic-based approach to herbal compositions

A technology for compositions and herbal medicines, applied in the fields of biochemical equipment and methods, combinatorial chemistry, special data processing applications, etc., capable of solving problems that have not been used to explore and prove cellular and molecular reactions, etc.

Inactive Publication Date: 2002-02-13
YALE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0037] As shown in the above review of relevant scientific literature, molecular-based techniques have not been used to explore and confirm the cellular and molecular responses of biological systems simultaneously treated or challenged by various compounds such as herbal TCM

Method used

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  • Phytomics: A genomic-based approach to herbal compositions
  • Phytomics: A genomic-based approach to herbal compositions
  • Phytomics: A genomic-based approach to herbal compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0134] Example 1. Construction of a standardized HBR array of selected herbal compositions.

[0135] figure 1 A basic scheme for building a standard HBR array is provided. The definition of each component of the scheme is provided by the text above.

[0136] After the herbal composition of interest is selected, data related to various properties of the herbal composition are collected, including but not limited to plant-related properties, markers, and biological response information.

[0137] Plant-related data include, but are not limited to, the species of the plant, specific plant parts, geographic origin of the plant in the herbal composition, growing conditions of the plant, processing methods used to prepare the herbal composition, storage methods and conditions, herbal composition various chemical analyses. The marker information includes marker qualitative and quantitative data collected after application of herbal compost to a biological system. Applicable marker...

Embodiment 2

[0143] Example 2. Establishment of batch HBR arrays of batch herbal compositions

[0144] figure 2 A basic protocol for building an HBR array of batch herbal medicinal compositions is provided. The definition of each component of the diagram is provided above. The procedure for building such an array is the same as described immediately above for the normalized HBR array.

[0145] Typically, the amount of data that needs to be collected for a batch of HBR arrays will be less than the amount of data that needs to be collected for building a standardized HBR array. However, the data collected for the batch herbal composition can be added to an established HBR array or used to create a new standardized array.

[0146] Typically, data that has been collected that is highly correlated or linked to the expected biological activity of the herbal composition being tested is the best data collected for the batch herbal composition. For example, if it has been determined that a par...

Embodiment 3

[0147] Example 3. Creation and use of master data sets.

[0148] image 3 A basic protocol for building and using a master dataset of herbal compositions is provided. The definition of each component of the diagram is provided above.

[0149] The first step is to build a master dataset of selected herbal compositions or batches of herbal compositions. This can be accomplished by applying the herbal composition to the biological system and collecting the corresponding marker information which will constitute the primary data set. Typically, but not occasionally, the primary data set will include genomic and / or proteomic data in the form of arrays, such as arrays obtained with DNA chips.

[0150] In a next step, the primary data set is analyzed to see if specific expression / results have been obtained for the tested herbal composition. Specific expression / results are necessary to generate meaningful algorithms in the next step. Examples of such specific expression / results in...

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PUM

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Abstract

The present invention provides the tools and methodologies necessary to guide the standardization of herbal compositions, to determine which specific components of a herbal composition are responsible for any particular biological activity, to predict the biological activities of a particular herbal composition, and for the development of improved herbal therapeutics. This invention provides the tools and methodologies for creating, maintaining, improving and utilizing Herbal BioResponse Arrays (HBR Arrays), wherein the HBR Arrays constitute data sets associated with particular herbal compositions. The HBR Arrays of the present invention may include information on the plant-related parameters of the herbal constituents, marker information collected following the exposure of a biosystem to the herbal composition, and biological response information collected following the exposure of a biosystem to the herbal composition.

Description

field of invention [0001] The present invention relates to herbal compositions. More specifically, the present invention provides tools and methods for improved screening, testing, quality control and production of herbal compositions to help guide the development of new herbal compositions and identify novel uses for existing herbal compositions. Background of the invention [0002] All publications and patent applications are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. [0003] Asians and Europeans have used herbs for centuries. In the United States (US), herbal medicines have become commercially valuable in the dietary supplement industry and holistic medicine. About 1 / 3 of the American population has tried some form of alternative medical treatment at least once. (Eisenberg et al., 1993, N. Eng. J. Med. 328:24...

Claims

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Application Information

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IPC IPC(8): G01N33/50C12N15/09C12Q1/68C12Q1/6809C12Q1/6897C40B40/02C40B50/06G01N33/15
CPCC12Q1/6897C12Q1/6809C12Q1/68
Inventor P·C·昆Y·C·程
Owner YALE UNIV
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