Zhonghua soft-shelled turtle aeromonad oral slow-releasing microsphere vaccinum and preparation process thereof

A technology of slow-release microspheres and Aeromonas, applied in antibacterial drugs, pharmaceutical formulations, bacterial antigen components, etc., to achieve low production costs, stable properties, and good social and economic benefits

Inactive Publication Date: 2002-10-02
ZHEJIANG UNIV
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  • Abstract
  • Description
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Problems solved by technology

However, so far, there is no literature report on the study of oral sustained-release microsphere vaccine of Aeromonas turtle

Method used

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  • Zhonghua soft-shelled turtle aeromonad oral slow-releasing microsphere vaccinum and preparation process thereof
  • Zhonghua soft-shelled turtle aeromonad oral slow-releasing microsphere vaccinum and preparation process thereof
  • Zhonghua soft-shelled turtle aeromonad oral slow-releasing microsphere vaccinum and preparation process thereof

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Embodiment Construction

[0016] The specific steps and processes of the present invention are detailed below: 1 Preparation and screening of strains

[0017] Aeromonas sobria was isolated from the liver, heart blood, and ascites of the Chinese soft-shelled turtle with hemolytic ascites disease, and it was successively passaged on nutrient agar medium to the 35th generation, and the culture characteristics and bacteria of different generations of strains were tested. Body antigenicity and virulence. Aeromonas sobria was continuously passaged on nutrient agar medium to 35 generations, and its biochemical characteristics did not change. There were no significant differences in the number of bacteria, the hemolytic value of extracellular products, the virulence, and the antigenicity of the inactivated bacteria with different generation strains as the basic seeds. It shows that Aeromonas sobria can be used as a good vaccine production strain. 2 Production strain culture conditions

[0018] Taking the bacterial...

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Abstract

The present invention discloses an aeromonad oral slow-released microsphere vacine for Chinese terrapin and its preparation method. It is microsphere vaccine made up by utilizing inactivated bacterial solution of Chinese terrapin common disease source-temperate aeromonad, using bio-degradable polymer material as carrier and adopting spray-drying method to make covering process. Its preparation method includes seven steps: preparing bacteria seed, cultivation, counting, inactivation, microsphere preparation, checking and analysis of immune effect. It can effectively prevent disease due to aeromonad.

Description

Technical field [0001] The invention relates to an oral sustained-release microsphere vaccine of Aeromonas sinensis and a preparation method thereof. Background technique [0002] Due to the development of my country's "one superior and two high" agriculture, turtles and other famous and special aquatic product breeding industries have developed rapidly. However, with the expansion of artificial turtle farming and the increase of intensification, turtle diseases are increasing day by day. Aeromonas disease is currently one of the main diseases in turtle farming, and it occurs in all growth stages of turtles, with an incidence rate of over 50%, causing the turtle industry to suffer huge economic losses. Due to the special physiological characteristics and ecological habits of turtles and the relative lag in the research of turtle disease control, the current turtle disease control mainly relies on antibacterial drugs and chemical disinfectants. These drugs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/52A61K39/02A61P31/04
Inventor 孙红祥
Owner ZHEJIANG UNIV
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