Method for creating animal model of rat's minimal brain dysfunction (MBD)

An animal model and construction method technology, which can be used in the field of animal model construction for evaluating methods of treating ADHD, screening and treating ADHD drugs, and can solve problems such as difficulty in completely treating ADHD.

Inactive Publication Date: 2002-11-13
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, there are still many unknowns in the pathological mechanism of ADHD, which needs to be further studied, especially at this stage, there is no ideal animal model of ADHD, which brings great difficulties to a thorough understanding of the pathological mechanism of ADHD and the complete treatment of ADHD

Method used

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  • Method for creating animal model of rat's minimal brain dysfunction (MBD)

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Embodiment Construction

[0018] The present invention is further described below by way of examples.

[0019] SD rats were selected, male, weaned rats (day 21 after birth), purchased from the Animal Center of Fudan University School of Medicine. After the animals were repurchased, they were randomly divided into groups and kept in separate cages. Maintain a quiet and comfortable environment during feeding, allowing them to drink water and eat freely. After the operation, in the two days before the start of the experiment, the experimenters stroked and grasped the rats once a day in the morning and afternoon, and let the rats get used to the experimental device and the instruments used, in order to eliminate as much as possible the stress, stimuli, Ensure the accuracy of the experimental results.

[0020] 1. Brain surgery

[0021] After the animals were weighed, they were anesthetized by intraperitoneal injection of sodium pentobarbital (40 mg / kg body weight). Fix the head of the animal, cut off th...

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Abstract

A method for creating the animal model of rat, which is used for screening the related medicine and evaluating the related therapy for restless syndrome, features that the specific antagonist "Yohimbine" for alpha-2 receptor is injected into the local region of the prefrontal lobe of rat with a micro-quantity to block the function of apha-2 receptor and directly induce the restless syndrome of the rat.

Description

technical field [0001] The invention belongs to the technical field of medical evaluation and detection, and in particular relates to a method for constructing an animal model for screening drugs for treating ADHD and evaluating methods for treating ADHD. Background technique [0002] Attention-deficit hyperactivity disorder (ADHD) is a common clinical behavioral disorder in children and adolescents, mainly characterized by attention deficit, hyperactivity and impulsiveness. The incidence of ADHD in school-age children is about 3% to 10%. Due to distraction and hyperactivity, children with ADHD cannot complete school classroom education, which seriously affects their mental development and growth. ADHD mostly starts from preschool age, some improve in late adolescence, and some have life-long problems, such as family and partnership problems, social isolation, substance abuse and other psychological problems. It is not difficult to see from this that ADHD will cause great ...

Claims

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Application Information

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IPC IPC(8): G09B23/36
Inventor 李葆明马朝林徐开静
Owner FUDAN UNIV
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