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Dual inhibitors of cholestery lester and wax ester synthesis for sebaceous gland disorders

A sebaceous gland, disease technology, applied in acne vulgaris, cystic acne, the compound has the following, acne, base ester first disclosed in U.S. Patent No. 5,49, senile acne and medicated acne, 20] The present invention provides a, The field of keratinizing acne, able to solve problems such as no disclosure

Inactive Publication Date: 2003-02-19
WARNER-LAMBERT CO
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the compound [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester is not disclosed in EP0699439A2 or the references incorporated therein

Method used

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  • Dual inhibitors of cholestery lester and wax ester synthesis for sebaceous gland disorders
  • Dual inhibitors of cholestery lester and wax ester synthesis for sebaceous gland disorders

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Embodiment Construction

[0023] The present invention provides a method for treating sebaceous gland diseases, comprising administering an effective amount of [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2 to a patient in need of said treatment. , a compound of 6-diisopropyl-phenyl ester or a pharmaceutically acceptable salt thereof. The compound [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester (its common name is also called avasimibe) was first disclosed in the United States Patent No. 5,491,172 and divisional patent U.S. Patent No. 5,633,287. Avasimibe or a compound of formula I has the following structure:

[0024]The present invention provides a method for treating sebaceous gland diseases in mammals, especially humans, comprising administering a therapeutically effective amount of a compound of formula I [(2,4,6-triisopropyl-phenyl)-acetyl]-amino 2,6-diisopropyl-phenylsulfonic acid ester or a pharmaceutically acceptable salt thereof.

[0025] Furthermore...

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Abstract

The present invention provides a method of treating sebaceous gland disorders comprising administering to a patient in need of said treatment an effective amount of a compound named [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diiso-propyl-phenyl ester or a pharmaceutically acceptable salt thereof. Particularly, methods of treating sebaceous gland disorders are provided wherein said disorders are selected from seborrhea, acnes, perioral dermatitis, rosacea, and corticosteroid-induced acneiform lesions. The present invention provides methods of treating acnes such as, for example, chloracne, ciliaris acne, cystic acne, keratosa acne, vulgaris acne, senile acne, and medicinal acne.

Description

Background of the invention [0001] The present invention relates to a compound named [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester or its pharmaceutically acceptable Method in the treatment of sebaceous gland diseases by accepting halosteroids. In particular, the present invention provides a method of treating a sebaceous gland disorder, wherein said disorder is selected from the group consisting of seborrhea, acne, perioral dermatitis, rosacea and corticosteroid-induced acneiform lesions. [0002] Acne is a group of skin disorders associated with a variety of etiologies. Such acne includes chloracne, ciliary acne, cystic acne, keratotic acne, and acne vulgaris. In its acne vulgaris, it appears mainly in the face and trunk area, affecting the patient's appearance. It can cause more mental distress and, from a physical point of view, afflicts the sufferer more severely than many other diseases. [0003] The basic lesion common to the acne f...

Claims

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Application Information

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IPC IPC(8): A61P17/00A61K31/00A61K31/255A61P17/08A61P43/00
CPCY10S514/864A61K31/255A61P17/00A61P17/08A61P17/10A61P43/00
Inventor R·霍曼
Owner WARNER-LAMBERT CO
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