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Method for quiding gene into local part or humanbody by shoe-type catheter

A catheter and shoe-type technology, applied in the field of medical molecular biology, can solve problems such as unclearness, and achieve the effects of no toxic side effects, direct guidance, and prevention and treatment of cardiovascular diseases.

Inactive Publication Date: 2003-08-27
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

How to introduce genes with this catheter? How? It is not clear whether it can inhibit the expression of genes in the body, etc.

Method used

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  • Method for quiding gene into local part or humanbody by shoe-type catheter
  • Method for quiding gene into local part or humanbody by shoe-type catheter
  • Method for quiding gene into local part or humanbody by shoe-type catheter

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Experimental program
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Embodiment Construction

[0046] The present invention will be described and discussed in further detail below in conjunction with the accompanying drawings. 5.1 Feasibility of shoe-type catheter for local drug delivery 5.1.1 Local drug delivery catheter

[0047] The shoe catheter (Local Med Inc, USA) was provided by the University of Utah School of Medicine and LDS Hospital. It consists of an outer sheath for drug administration and the lumen of the PTCA balloon catheter. There are many side holes on the surface of the tip of the outer sheath, through which any type of standard PT-CA balloon catheter can be sent into, and the outer sheath and blood vessels Shaped catheters have a separate lumen and two distinct pressure channels (see Figure 1A , 1B ). When in use, the standard angioplasty catheter is first sent through the inner lumen of the sheath tube. At the target blood vessel, after the balloon is formed, the balloon is loosened, and then the administration area at the tip of the outer sheath ...

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Abstract

The present invention discloses a method for targeted in-vivo local introduction of gene medicine by utilizing calceolate conduit. It is characterized by that its location is accurate, it can directly introduced into cardiovascular target point, it is simple and easy, has no toxic side effect, and can be used in clinical application. The medicine concentration at the target point into which the medicine is locally introduced by calceolate conduit has pressure dependence in a certain range, and the high concentration of the medicine can be continued for 24 hr, and the gene medicine locally-introduced in-vivo can inhibit expression of internal some genes produce the action of preventing and curing cardiovascular diseases.

Description

1. Technical field [0001] The invention belongs to medical molecular biology technology, and relates to a method for introducing genes, in particular to a method for locally introducing genes in a shoe-shaped catheter. 2. Background technology [0002] How to position the target gene drug into target sites such as the cardiovascular system of living animals, so as to inhibit the expression of certain genes, is a key step in the use of gene drug to prevent and treat cardiovascular diseases. Although the current gene transfer methods such as retrovirus, adenovirus, and viral liposomes have achieved gratifying results in animal experiments [1，2，3] , but due to many unpredictable side effects [1] , the use of introducing genes in vivo is very limited, and it is difficult to be used in clinical practice. Directly introducing gene drugs into the outer membrane in vivo, although animal experiments are feasible [4] , but it is difficult to be used clinically. Using a balloon cath...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61M31/00
Inventor 兰燕平
Owner XI AN JIAOTONG UNIV
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