Promoting whole body health

A systemic and healthy technology, applied in chlorine active ingredients, dentistry, oral care, etc., can solve the problem of no research verifying the beneficial effects of periodontal treatment compositions on systemic diseases

Inactive Publication Date: 2003-09-03
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] However, as stated by R.C.Williams and S.Offenbacher in Periodontology 2000, Vol. 23, pp. 9-12 (June 2000), no studies have so far verified the conclusions of the beneficial effects of periodontal compositions on systemic disease
The authors further report that no periodontal treatment to date has been specifically designed to improve systemic health

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0084] The subgingival gels of the present invention can be prepared using polymeric carrier systems comprising various types of polymers, including those safe for use in the oral cavity and wounds of humans or other animals. Such polymers are known and include, for example, polymers and copolymers such as polylactic acid ("PLA"), polyglycolic acid ("PLG") and polylactic-co-glycolic acid ("PLGA"), polyamino acids ( Such as polyasparagine, chitosan, collagen, polyalbumin, gelatin and hydrolyzed animal protein), polyvinylpyrrolidone, xanthan gum and other water-soluble gums, polyanhydrides and polyorthoesters. Preferred are polymers and copolymers of polylactic acid (PLA), polyglycolic acid (PLG) and polylactic-co-glycolic acid (PLGA). Particularly preferred polymers useful in the present invention are copolymers containing a mixture of lactide and glycolide monomers. Lactide monomer preferably comprises about 15%-85%, preferably about 35%-65% polymer, while glycolide monomer c...

Embodiment

[0165] The following examples were prepared by mixing the following materials by conventional means:

[0166] Dentifrice phase

Chlorite phase

Element

weight%

Element

weight%

water

Sorbitol (70% solution)

Glycerin

Sodium carbonate

sodium fluoride

Propylene Glycol

Hydrated silica

xanthan gum

carboxymethyl cellulose 1

Sodium Alkyl Sulfate (27.9% solution)

Titanium dioxide

sodium saccharin

essence

Methylparaben

Propyl Paraben

20.680

18.534

9.000

1.000

0.486

8.000

30.00

0.500

0.400

8.000

0.700

0.600

2.000

0.070

0.030

Sodium chlorite (80%)

Carbopol 956 2

water

Sodium carbonate

sodium bicarbonate

sodium hydroxide

pH of the chlorite phase

≈10

3.75

5.62

86.89

0.53

0.42

2.79

...

Embodiment 7

[0186] Example 7: In a small dose cup with a lid, 1.847 grams of dry powder mix was added to 15 ml of water. Stir vigorously until the solid dissolves, rinse mouth with it and spit out.

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PUM

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Abstract

The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising a safe and effective amount of chlorite ion in admixture with a pharmaceutically acceptable carrier, said compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and inhibiting the spread into the bloodstream of oral pathogenic bacteria and associated bacterial toxins and resultant inflammatory cytokines and mediators. The present invention also encompasses methods of use of these compositions by topically applying to the oral cavity, a safe and effective amount of chlorite ion to promote and / or enhance whole body health in humans and other animals.

Description

field of invention [0001] The present invention relates to the promotion and enhancement of general health or systemic health in humans and other animals by the use of topical oral compositions comprising an effective amount of chlorite ion effective in controlling bacterial mediated disease and conditions in the oral cavity and inhibits the spread of oral pathogens, their associated bacterial toxins and endotoxins and inflammatory cytokines and mediators facilitated by these oral pathogens. In particular, the present invention relates to methods of using the topical oral compositions of the present invention to reduce the risk of developing cardiovascular disease, stroke, atherosclerosis, diabetes, severe respiratory infections, premature and low birth weight, postpartum neurological Increased risk of mortality associated with developmental dysfunction and reduction in oral disease and symptoms through treatment and prevention. Background of the invention [0002] Recent r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/00A61K8/20A61K8/36A61K8/40A61K8/41A61K8/42A61K8/44A61K8/49A61K8/64A61K8/66A61K33/20A61Q11/00
CPCA61K8/20A61K33/20A61Q11/00
Inventor M·J·多伊尔S·J·亨特-林德尔R·E·小辛格R·L·维马拉塞尔
Owner PROCTER & GAMBLE CO
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