Dextromethorphan hydrobromide drop pills and preparation process thereof

A technology of dextromethorphan hydrobromide and dripping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems affecting drug stability, etc., and achieve the effect of low cost and simple preparation method

Inactive Publication Date: 2003-10-22
山东禹王制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Therefore, the dropping pills of various medicines appear one after another, and the melting temperature of dextromethorphan hydrobromide is 125 degrees Celsius, which is close to the muddy temperature, so the direct dripping of pills with the hot melting method affects the stability of the medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] This embodiment takes the preparation of 1000 dextromethorphan hydrobromide dropping pills with a content of 7.5 mg as an example.

[0015] Weigh 7.5 grams of dextromethorphan hydrobromide, 15 grams of polyethylene glycol 6000, 7.5 grams of polyethylene glycol 10000, 3.8 grams of glycerin and 0.56 grams of Tween-80. Put it in a container and mix evenly, heat to 85 degrees, and keep stirring at this temperature, so that the material is completely in a uniform melting state.

[0016] Then, drop the above-mentioned molten material into methyl silicone oil, and make it condense to form a pellet. The above-mentioned materials can drop about 1000 pills, and each pill contains 7.5 mg of active ingredient dextromethorphan hydrobromide.

[0017] Then the dropping pills in the silicone oil are taken out, and the silicone oil is removed, dried and coated to form finished pills.

[0018] The fusing point of dextromethorphan hydrobromide used in the present invention is 125 degree...

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Abstract

The present invention discloses a dextromethorphan hydrobromide dripping pills. It is made up by heating dextromethorphan hydrobromide, polyethylene glycol, glycerine and Tween-80, comelting them and retaining comelting state, drop-adding them into methyl silinon oil condensate and forming dripping pills. It is simple in preparation process and low in cost, at the same time the dissolution of said dripping pills can be reached to 90% of labelled amount within 15 min., and is higher than that of tablet. Said dripping pills can be dissolved inwater, can be substituted for solution preparation, and its stability is far better than that of solution preparation.

Description

technical field [0001] The invention relates to a preparation reform of commonly used medicines, in particular to dextromethorphan hydrobromide dropping pills. The present invention also relates to the preparation method of the dropping pill. Background technique [0002] Dextromethorphan hydrobromide is as a kind of commonly used medicine, and its traditional preparation form is a tablet, and the dissolution rate of this tablet is generally limited to when 30 minutes, and the dissolution amount is 80% of the marked amount. At the same time, there is dust pollution in the production process of the tablet, and the production equipment is complicated, the floor area is large, and the cost is high. In addition, there is also a dextromethorphan hydrobromide solution preparation, which can be taken by children, but it also has the problems of inconvenient carrying and poor stability. [0003] As a new type of pharmaceutical preparation, the drop pill preparation has the advanta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/435A61P11/14
Inventor 张以成刘锡潜
Owner 山东禹王制药有限公司
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