Notiginseng total saponin liposome and its preparation

A technology of total saponins and total saponins of Panax notoginseng, which is applied in the directions of liposome delivery, pill delivery, aerosol delivery, etc., can solve the problems affecting the stability of liposomes of total notoginseng saponins, phospholipids are prone to hydrolysis and oxidation reactions , thermodynamic instability, etc.

Inactive Publication Date: 2004-04-28
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, because notoginseng total saponin liposome belongs to colloid dispersion system, belongs to thermodynamically unstable system, its membrane material component phospholipid is prone to hydrolysis and oxidation reaction, and the temperature of external environment, pH value easily cause the change of liposome structure, thereby Cause the leakage of drugs in liposomes and affect the stability of liposomes with total saponins of notoginseng during storage
This is a technical problem that has not been well solved for a long time

Method used

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  • Notiginseng total saponin liposome and its preparation
  • Notiginseng total saponin liposome and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0206] Dissolve 30g of Panax notoginseng saponins in pH7.2 phosphate buffer, add 120g of soy phospholipid, 50g of cholesterol, and 10g of dicetyl phosphate dissolved in 200ml of chloroform under nitrogen flow, and evaporate under reduced pressure to remove the chloroform. The residual liquid is dispersed by ultrasonic to disperse liposomes, and diluted with an appropriate amount of buffer solution to obtain the total saponins liposome solution of notoginseng.

Embodiment 2

[0208] Dissolve 40 g of lecithin and 50 g of cholesterol in ether, add 8 g of panax notoginseng saponins solution prepared with 4 mmol / L phosphate buffer solution, treat with ultrasonic for 2 minutes, and immediately rotate and evaporate under reduced pressure on a water bath until it appears gel After vortexing to make the gel phase inversion, then continue to evaporate to remove the ether, ultracentrifuge for 30 minutes to separate and remove the unincorporated total saponins of Panax notoginseng, wash the precipitate twice with water, centrifuge to obtain the precipitate, use 10mmol / L phosphoric acid The total saponin liposome solution of Panax notoginseng is obtained by diluting the salt buffer solution.

Embodiment 3

[0210] Take 80g of egg yolk lecithin, 20g of cholesterol, and 10g of octadecylamine, dissolve it in absolute ethanol and dissolve it in ethanol. Remove the ethanol under reduced pressure to form a membrane. Add 10g of panax notoginseng saponins in phosphate buffer solution and shake to make the membrane. Take it off, ultrasonic treatment for 20 minutes, and centrifuge to remove unencapsulated drugs to obtain liposome suspension.

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Abstract

The present invention discloses total notoginseng saponin liposome and its preparation. The total notoginseng saponin liposome contains total notoginseng saponin 5-30 wt%, filming material 50-80 wt%, additive 1-10 wt% and some other supplementary material. It may be prepared into transdermal preparation, aerosol, oral liquid, eye preparation, tablet or capsule; is used in treating apoplexy, hemiplegia, atherosclerotic thrombotic cerebral infarction, cerebral embolism, etc.; and has excellent medicinal application foreground.

Description

Technical field [0001] The present invention relates to liposome pharmaceutical preparations. More specifically, the present invention relates to notoginseng total saponins liposomes and pharmaceutical preparations containing notoginseng total saponins liposomes. Background technique [0002] Panax notoginseng (Panax notoginseng) is a plant of the genus Araliaceae, and its root is used for medicine. So far, more than 20 monomeric saponins have been isolated from Panax notoginseng, with an average total glycoside content of 7.87%, as well as 0.38% of flavonoids, 0.90% of panax notoginseng, and 0.28% of active polysaccharides. In addition, there are more than 17 kinds of amino acids in Panax notoginseng, with an average content of 7.73%, 73 kinds of volatile oil components of 0.40%, 17 kinds of trace elements including active selenium, and up to 8.8% of crude protein and other chemical substances. The content of the total saponins of Panax notoginseng, the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/127A61K9/20A61K9/48A61K31/704A61P7/02A61P9/10A61P27/02
Inventor 周志宏梅艳熊毅
Owner YUNNAN PHYTOPHARML
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