Technical method for extracting oridinin from rabdosia rubescens

A technology of oridonin and process method, which is applied in the field of extracting oridonin, which can solve the problem that it is difficult to obtain pure oridonin, tannins and polysaccharides cannot be removed well, and Eliminate oridonin and other problems, achieve the effect of saving elution time, saving solvent consumption, and improving product purity
CN1528757AInactive Publication Date: 2004-09-15EAST CHINA UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
EAST CHINA UNIV OF SCI & TECH
Publication Date
2004-09-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention advances a new technique proper to separate and purify oridonin. It adopts alcohol solution extraction, then makes water float reflux treatment, where the water float liquor directly passes through the column of macroporous resin (like HZ-841 macroporous absorbing resin) polymerized of styrene and divinylbenzene as monomers to eliminate sugar, pigment, etc, adopts silica gel and magnesium chloride mixed column chromatography to separate and elute, and finally recrystallize to obtain higher purity oridonin. It is safe, low-cost, and applied to industrialized production.
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Description

technical field

[0001] The present invention relates to a new process method for extracting Rubescensine A from Rubescens. Background technique

[0002] Drug research shows that Rubescens has good anti-inflammatory, antibacterial and analgesic effects, and can effectively inhibit type A and B hemolytic streptococcus, Staphylococcus aureus and so on. It has obvious cytotoxic effect on Hela cells cultured in vitro, human esophageal cancer 109 cells and liver cancer BEL-7402 cells. 180 , P 388 , L 1210 Liver cancer and AKS have obvious anti-tumor effects, and Rubescensine A has a mild inhibitory effect on esophageal epithelial hyperplasia. Among them, Rubescensine A, the diterpenoid component, is an effective anti-tumor component, so it is known as "penicillin" and "natural antibiotic" in traditional Chinese medicine. And the United States is also studying the use of Rubescens for the prevention and treatment of AIDS. The development of Rubescensus will become the "sunrise...

Claims

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