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Panaxadiol saponin preparation with biological activity and use

A technology of ginsenoside and biological activity, which is applied in the direction of organic active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of destroying ginsenosides, improve hemodynamics, and improve the quality of life and work efficiency, improved sleep duration and sleep quality

Inactive Publication Date: 2004-09-29
昆明杉榆生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the ginsenosides that are easy to be hydrolyzed will be destroyed by strong alkali.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] 1. Take 100 grams of ginsenosides, dissolve in 500 ml of 90% ethanol and stir;

[0055] 2. Add 2000 ml of acetone while stirring, and after fully stirring, set it at 15°C for more than 8 hours, and filter to obtain a filter cake;

[0056] 3. Put the above filter cake on the silica gel column, and use CHCl 3 :CH 3 OH=7:3 solvent elution, collect 1000 milliliters of the eluate containing panaxatriol saponin, concentrate, dry, obtain panaxatriol saponin:

[0057] 4. Continue eluting with 7000 ml of methanol with a concentration of 99%, collect and concentrate the methanol eluate, and dry to obtain ginsengdiol saponins with a content greater than 45%;

[0058] 5. The above-mentioned ginsengdiol saponin is further subjected to silica gel column chromatography, and is purified with CHCl 3 :CH 3 OH=3:7 solvent elution, collection, and repeated several times to obtain ginsengdiol saponins with a content of 90%.

Embodiment 2

[0060] 1. Take 100 grams of ginsenosides, dissolve in 700 ml of 70% ethanol and stir;

[0061] 2. Add 3000 ml of acetone while stirring, and after fully stirring, set it at 15°C for more than 8 hours, and filter to obtain a filter cake;

[0062] 3. Put the above filter cake on the silica gel column, and use CHCl 3 :CH 3 OH=7:3 solvent elution, collect 1000 milliliters of the eluate containing panaxatriol saponin, concentrate and dry to obtain panaxatriol saponin;

[0063] 4. Continue eluting with 7000 ml of methanol with a concentration of 99%, collect and concentrate the methanol eluate, and dry to obtain ginsengdiol saponins with a content greater than 45%;

[0064] 5. The above-mentioned ginsengdiol saponin is further subjected to silica gel column chromatography, and is purified with CHCl 3 :CH 3 OH=3:7 solvent elution, collection, and repeated several times to obtain ginsengdiol saponins with a content of 90%.

Embodiment 3

[0066] Get material by following formula, adopt existing process method to make 1000 bags of ginseng diol saponin granules, and every bag weighs 3.5g:

[0067] Panaxadiol saponins (Rb 1 =45%) 125g

[0068] 3000g cane sugar

[0069] Dextrin 400g

[0070] Alcohol in moderation.

[0071] Take once a day, one bag each time (before going to bed).

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PUM

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Abstract

Panaxadiol saponin is prepared into food product or medicine preparation capable of repairing damaged or fatigued cerebral cell and cerebral nerve cell, treating and improving insomnia and amnesia caused by long term intense nerve, improving haemodynamic and blood quality, improving brain function, and improving sleep quality.

Description

technical field [0001] The invention relates to a bioactive preparation, especially a preparation containing panaxadiol saponin and its application in the field of pharmacy. Background technique [0002] Ginseng is also called Korean ginseng, American ginseng, Panax notoginseng, also known as Tianqi, etc., all of which are plants of the genus Panax of Araliaceae. Its roots, leaves, flowers, etc. all have medicinal value, and the ginsenosides, American ginsenosides and Panax notoginseng saponins extracted from these plants are all composed of Rb 1 Mainly panaxadiol saponins and Rg 1 Mainly composed of panaxatriol-type saponins. Panaxadiol-type saponins and panaxatriol-type saponins have very similar effects in improving the hemodynamics of blood circulation, reducing blood viscosity, reducing blood lipids, etc., as disclosed in Chinese patent ZL89100070. And its pharmaceutical composition and application", wherein, the preparation method is to dissolve said total saponins ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P25/00
Inventor 艾黎
Owner 昆明杉榆生物技术有限公司
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