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Art for extracting red sage root water soluble ingredient and removing impurities

A water-soluble, Danshen technology, applied in the field of pharmacy, can solve problems such as cumbersome steps, uneconomical, and pain

Inactive Publication Date: 2004-10-20
上海正大通用药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(1) Incomplete removal of impurities, poor clarity of the product and pain during injection
(2) Two alcohol precipitation steps are adopted, the amount of ethanol is larger, the price is more expensive, and it is uneconomical
(3) Filtration after water sinking is more difficult
(4) The steps are cumbersome and take a long time

Method used

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  • Art for extracting red sage root water soluble ingredient and removing impurities

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Decoct 1000g of salvia miltiorrhiza with water for three times, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to 480ml. Use 5% hydrochloric acid solution to acidify the pH value to 3.5, let it stand for 16 hours, filter, add ethanol to the filtrate until the alcohol content is 75%, let it stand in a cold place for 48 hours, filter, and adjust the pH value of the filtrate to 7.5, stand in the cold place for 24 hours, filter, adjust the pH value to 7.0 with 5% hydrochloric acid solution, recover ethanol, concentrate to 120ml, add the concentrate to 880ml water for injection, refrigerate for 16 hours, filter, concentrate the filtrate to 250ml, refrigerate After 72 hours, add 0.4% activated carbon and boil for 30 minutes, refrigerate for 24 hours, filter, adjust the pH value to 6.8 with 5% sodium hydroxide solution, and obtain it after filtration.

[0073] The absorbance (281 ± 3nm) of the prepared Danshen extract is 0.730, pH value, sterili...

Embodiment 2

[0075] Decoct 1000g of Danshen crude drug with water three times, 2 hours each time, combine the decoction, filter, concentrate the filtrate to 480ml, acidify the pH value to 2.8 with 20% hydrochloric acid solution, let it stand for 12 hours, filter, add ethanol to the filtrate to reach the alcohol content 80%, stand in a cold place for 48 hours, filter, adjust the pH value of the filtrate to 8.0 with 20% sodium hydroxide solution, let it stand in a cold place for 12 hours, filter, adjust the pH value to 6.0 with 20% hydrochloric acid solution, and recover ethanol. Concentrate to 120ml, add the concentrate to 880ml of water for injection, refrigerate for 16 hours, filter, concentrate the filtrate to 250ml, refrigerate for 72 hours, add 0.3% activated carbon to boil for 30 minutes, refrigerate for 24 hours, filter, adjust with 20% sodium hydroxide solution When the pH value reaches 6.8, it can be obtained after filtration.

[0076] The absorbance (281 ± 3nm) of the prepared Dan...

Embodiment 3

[0078] Decoct 1000g Danshen crude drug with water for three times, 2 hours each time, combine the decoction, filter, concentrate the filtrate to 500ml, acidify the pH value to 2.0 with 30% hydrochloric acid solution, let it stand for 8 hours, filter, add ethanol to the filtrate to reach the alcohol content 85%, stand in the cold place for 48 hours, filter, adjust the pH value of the filtrate to 8.5 with 40% sodium hydroxide solution, let it stand in the cold place for 8 hours, filter, adjust the pH value to 5.0 with 30% hydrochloric acid solution, and recover ethanol. Concentrate to 120ml, add the concentrate to 880ml of water for injection, refrigerate for 16 hours, filter, concentrate the filtrate to 250ml, refrigerate for 72 hours, add 0.1% activated carbon to boil for 30 minutes, refrigerate for 24 hours, filter, adjust with 40% sodium hydroxide solution When the pH value reaches 6.8, it can be obtained after filtration.

[0079] The absorbance (281 ± 3nm) of the prepared ...

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Abstract

A process for extracting the water-soluble components from red-sage root and purifying it features the combination of water-extracting and alcohol deposition method, acidic deposition method, and alcohol solution pH-regulating method. Its advantages are low cost, high speed and high purity effect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to an impurity removal process in the extraction process of water-soluble components of salvia miltiorrhiza. Background technique [0002] The traditional Chinese medicine Salvia miltiorrhiza has the effects of promoting blood circulation and removing blood stasis, nourishing blood to calm the nerves, cooling blood and eliminating carbuncle. Danshen preparations, such as Danshen injection, compound Danshen injection (Xiangdan injection, Danxiang Guanxin injection), Danshen large infusion, and compound Danshen large infusion, which are prepared from the water-soluble components of Danshen, have the functions of dilating blood vessels and increasing coronary arteries. The role of blood vessel volume has been widely used in the treatment of coronary heart disease, chest tightness, angina pectoris, myocardial infarction and ischemic stroke, and has become a commonly used clinical drug for treati...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61P9/10
Inventor 陈伟
Owner 上海正大通用药业股份有限公司
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