A liquid pharmaceutical formulation comprising nicotine for the administration to the oral cavity
A technology of liquid medicine and nicotine, applied in the direction of drug combination, drug delivery, medical preparations of non-active ingredients, etc., can solve the problem that the means and methods do not satisfactorily meet the teachings of NRT, cannot provide nicotine, and do not meet the requirements of tobacco User addiction and other issues
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Embodiment 1
[0160] 1000 ml of a formulation containing 10 mg nicotine / ml and approximately pH 8.5 was prepared.
[0161] Mixture 1
[0162] Into a beaker containing 800 ml of water at 90°C were added 0.7 g of methylparaben as a preservative, and 0.3 g of propylparaben as a preservative. Additives were dissolved during stirring for about 10 minutes. Then 10.45 g of sodium dihydrogen phosphate as a buffer and 0.5 g of EDTA as a chelating agent were added to the solution, and the solution was stirred for about 5 minutes. The solution was then cooled to 30°C during stirring.
[0163] mixture 2
[0164] To a beaker containing 15.9 g of ethanol as a solvent at room temperature was added 0.045 g of peppermint oil as a flavor. The liquid was mixed for 2 minutes.
[0165] final mixture
[0166] Mixture 2 was added to a beaker containing 150 ml of water during stirring. Slowly add 10 g of nicotine (base) to the beaker. Mixture 1 was then added to the beaker and stirred for 5 minutes. ...
Embodiment 2
[0168] 1000 ml of a formulation containing 10 mg nicotine / ml and approximately pH 7.0 is prepared.
[0169] Example 2 differs from Example 1 only in pH. The formulation of Example 2 contained a non-basifying buffer. This preparation is used for figure 2 Comparison.
[0170] Mixture 1
[0171] Into a beaker containing 800 ml of water at 90°C were added 0.7 g of methylparaben as a preservative, and 0.3 g of propylparaben as a preservative. Additives were dissolved during stirring for about 10 minutes. Then 10.45 g of sodium dihydrogen phosphate as a buffer and 0.5 g of EDTA as a chelating agent were added to the solution, and the solution was stirred for about 5 minutes. The solution was then cooled to 30°C during stirring.
[0172] mixture 2
[0173] To a beaker containing 15.9 g of ethanol as a solvent at room temperature was added 0.045 g of peppermint oil as a flavor. The liquid was mixed for 2 minutes.
[0174] final mixture
[0175] Mixture 2 was added to ...
Embodiment 3
[0177] 1000 ml of a formulation containing 10 mg nicotine / ml and approximately pH 6.0 is prepared.
[0178] Example 3 differs from Example 1 only in pH. The formulation of Example 3 included a non-basifying buffer. This preparation is used for figure 2 Comparison.
[0179] Mixture 1
[0180] Into a beaker containing 800 ml of water at 90°C were added 0.7 g of methylparaben as a preservative, and 0.3 g of propylparaben as a preservative. Additives were dissolved during stirring for about 10 minutes. Then 10.45 g of sodium dihydrogen phosphate as a buffer and 0.5 g of EDTA as a chelating agent were added to the solution, and the solution was stirred for about 5 minutes. The solution was then cooled to 30°C during stirring.
[0181] mixture 2
[0182] To a beaker containing 15.9 g of ethanol as a solvent at room temperature was added 0.045 g of peppermint oil as a flavor. The liquid was mixed for 2 minutes.
[0183] final mixture
[0184] Mixture 2 was added to a...
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