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Medicine for treating oral ulcer, gastric ulcer, burn and scald and traumatic infection and preparing method

A technology for oral ulcers and gastric ulcers, which is used in gastric ulcers, treatment of oral ulcers, preparation of various preparations of total flavonoids extract of hollyhocks, medicines for traumatic infections, and burns and scalds. And other issues

Active Publication Date: 2005-05-18
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The side effects of Western medicine are relatively large, and long-term use will also cause harm to other organs in the body, and it cannot be eradicated, and it is easy to relapse

Method used

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  • Medicine for treating oral ulcer, gastric ulcer, burn and scald and traumatic infection and preparing method
  • Medicine for treating oral ulcer, gastric ulcer, burn and scald and traumatic infection and preparing method
  • Medicine for treating oral ulcer, gastric ulcer, burn and scald and traumatic infection and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Put 20 kg of hollyhock flowers in an extraction tank, add 15 times the amount of 80% ethanol, extract twice, each time for 1 hour, combine the extracts, filter, and concentrate the filtrate into a concentrated solution with a relative density of 1.13-1.16 (60°C); Add an appropriate amount of water to dilute, pass through a macroporous adsorption resin column, and use alcohol-water gradient elution, 3 column volumes for water elution, 3 column volumes for 10% and 30% ethanol, and 1 column volume for 70% ethanol elution . The eluate is concentrated, dried and pulverized to obtain the total flavonoid extract, and the total flavonoid content is 5-95%.

Embodiment 2

[0089] Put 20 kg of hollyhock flowers in an extraction tank, add an appropriate amount of 70% ethanol, extract twice, each time for 1 hour, combine the extracts, filter, and concentrate the filtrate into a concentrated solution with a relative density of 1.13-1.16 (60°C), add an appropriate amount Settled in water for 24 hours, filtered with suction, concentrated to the corresponding volume, passed through a macroporous adsorption resin column, and eluted with alcohol-water gradient, 3 column volumes for water elution, 3 column volumes for 10% and 30% ethanol respectively, 70 % ethanol for 1 column volume. The eluate is concentrated, dried and pulverized to obtain the total flavonoid extract, and the total flavonoid content is 5-95%.

Embodiment 3

[0091]Put 20 kg of hollyhock flowers in an extraction tank, add 20 times the amount of 60% ethanol, extract twice, each time for 1 hour, combine the extracts, filter, and concentrate the filtrate into a concentrated solution with a relative density of 1.13 to 1.16 (60°C). Add an appropriate amount of water to sink for 24 hours, filter with suction, concentrate to the corresponding volume, pass through a polyamide column, and use alcohol-water gradient elution, 3 column volumes for water elution, 3 column volumes for 10% and 30% ethanol respectively, 70 % ethanol for 1 column volume. The eluate is concentrated, dried and pulverized to obtain the total flavonoid extract, and the total flavonoid content is 5-95%.

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Abstract

The medicine for treating oral ulcer, gastric ulcer, burns, scalds and traumatic infection is prepared with extracted total sunset hibiscus flower flavone as main active component. The extraction process of total sunset hibiscus flower flavone and the preparation process of different total sunset hibiscus flower flavone preparations are also provided.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a medicine for treating oral ulcers, gastric ulcers, burns, and traumatic infections (boils), and also relates to a preparation method of the medicine intermediate, total flavonoids extract of hollyhock flowers, and hollyhock flowers Preparation method of various preparations of total flavonoid extract. Its dosage forms include tablets, patches, films, sprays, gels, powders, solutions, powder sprays, capsules, dropping pills, soft capsules, granules, syrups, oral liquids, injections, and other dosage forms. Background technique: [0002] Oral ulcers, known as aphthous ulcers in traditional Chinese medicine, are the most common diseases of the oral mucosa. The clinical manifestations are repeated isolated round or oval superficial ulcers in the oral mucosa. The main symptom of oral ulcers is obvious burning pain in the local area. , and aphtha can occur in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P1/02A61P1/04A61P17/02
Inventor 张玲凌沛学卢志强胡庆文刘妍妍赵春荣
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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