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Effective part prepn for treating cardiac and cerebral vascular diseases and its prepn process

A technology of effective parts, cardiovascular and cerebrovascular, applied in the field of preparation of effective parts and its preparations, can solve the problems of unsuitability for industrial production and low yield

Inactive Publication Date: 2006-03-01
曹明成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the effective fraction of total flavonoids in hollyhock flower reaches more than 80% and there are no literature reports as raw materials for injection preparations. Basically be the bigger organic solvent of toxicity, and yield is low, therefore, existing extraction separation method is not suitable for industrialized production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0028] Take 5000 grams of hollyhock flowers, reflux 25 times of 75% ethanol solution for 2-3 times, each time for 1.5-2 hours, combine the obtained filtrates, recover ethanol under reduced pressure below 80°C until there is no alcohol smell, and use 4- Dissolve in 6 times hot water, let cool, centrifuge, put the liquid supernatant on a polyamide column, wash the column with deionized water until the color is very light, then wash with 75% ethanol until the color is very light, and eluate at 70°C Dry under reduced pressure to obtain 105 g of the effective part of the crude product.

[0029] Crude refinement:

[0030] Purification of raw materials for injection preparations: take 40 g of the crude product, reflux extraction twice with ethyl acetate 15-20 times, combine the filtrates, recover the solvent, and dry in vacuum to obtain 21 g of the product.

[0031] Measure the active part content in the above-mentioned raw materials respectively, and the results are as follows:

...

example 2

[0037] Take 5,000 grams of hollyhock flowers, use 25-30 times, 85% ethanol to extract 2-3 times, each time for 1.5-2.5 hours, combine the extracts and recover the ethanol under reduced pressure below 70 ° C until there is no alcohol smell, add the amount of crude drug 4 Dissolve in -6 times hot water, let cool, centrifuge, put the liquid supernatant on a polyamide resin column, wash the column with deionized water until the color is very light, then elute with 80% ethanol, collect the eluate, and store it below 80°C The ethanol was recovered under reduced pressure, and the extract was vacuum-dried to obtain 112 g of the active part of the crude product.

[0038] Refining of the effective part of the crude product:

[0039] Refining of raw materials for injection: Take 40 grams of the effective part of the crude product, heat and reflux extraction twice with ethyl acetate 15-20 times, each time for 1.5-2 hours, combine the extracts, recover the solvent, and vacuum-dry to obtain...

example 3

[0045] 1. Specification: 30mg / piece

[0046] 2. Prescription:

[0047] Active parts of hollyhock flower 30g

[0048] Mannitol 40g

[0049] Add water for injection to 5L

[0050] Make 1000 pieces

[0051] 3 preparation method:

[0052] Take the effective part of hollyhock flowers of the prescription, add appropriate amount of water for injection to dissolve in the beaker, then add mannitol to dissolve; measure pH3.4; add 0.1% activated carbon and heat and stir at 60°C for 15 minutes; decarbonize and filter, add water to the specified The volume is filtered with 0.45 μm and 0.22 μm filter membranes, the content is determined, and filled (5ml / bottle); pre-freeze for 24 hours and then dry in a freeze dryer; after drying, press the cap to obtain 1000 pieces.

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Abstract

The present invention discloses one kind of effective part preparation for treating cardiac and cerebral vascular diseases and its preparation process, and is especially the extracting method of effective part of sunset hibiscus for injection and the recipe and preparation process of the effective part preparation. The extraction process is suitable for industrial production and has the features of simple technological process and high yield. The present invention provides one new kind of Chinese medicine preparation for clinical application to treat cardiac and cerebral vascular diseases, including myocardial ischemia, cerebral ischemia, coronary heart disease, etc.

Description

Technical field: [0001] The invention relates to an effective part of a Chinese herbal medicine and a preparation method thereof, more specifically a method for extracting and separating the effective part of the dried flower of Abelmoschus manihot L. Medic, as well as a prescription and a preparation method of the effective part preparation. Background technique: [0002] Hollyhock is mainly used clinically to treat cardiovascular and cerebrovascular diseases, myocardial ischemia, cerebral ischemia, coronary heart disease, etc., and has a protective effect on ischemic and hypoxic brain damage. Its effective part is the flavonoid compound it contains. At present, there are no literature reports on the total flavonoids of hollyhock flowers reaching more than 80% as raw materials for injection preparations, only the separation methods and pharmacological activity reports of monomeric hyperin, etc., which are often separated by polyamide columns, and the elution solvent Basica...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P9/10
Inventor 曹明成
Owner 曹明成
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