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Injecta of anemarrhena extractive

A technology of Anemarrhena extract and injection, which is applied in the field of medicine and can solve the problems of low bioavailability, no visible and slow curative effect of active ingredients

Inactive Publication Date: 2005-06-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because oral administration has the disadvantages of slow curative effect and low bioavailability of active ingredients, it cannot meet the treatment needs of cardiovascular and cerebrovascular diseases with rapid onset, especially stroke patients still have difficulty swallowing in the acute stage. Therefore, if the activity of Zhimu Substance-Anemarrhena extract with saponin as the main component can be prepared into injection form to overcome the shortcomings of oral preparations, especially suitable for the treatment of cardiovascular and cerebrovascular diseases
However, there is no report about the injection form of Anemarrhena extract, nor is there any report that Anemarrhena is used as a drug for the treatment of ischemic cerebrovascular diseases

Method used

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  • Injecta of anemarrhena extractive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] The preparation of embodiment 1 Anemarrhena extract

[0105] Cut Anemarrhena into thin slices, take 10kg, infiltrate in 30L of 30% ethanol for 12 hours, extract by percolation, and collect 240L of percolation liquid. Concentrate the percolation liquid to 15L; filter the concentrated liquid, pass the filtrate into a chromatographic column equipped with 20L D101 resin, and successively elute with 300L of distilled water, 300L of 20% ethanol, and 120L of 60% ethanol, and collect 60% ethanol for elution Part; the 60% ethanol eluate was concentrated to 10L under reduced pressure, passed into a chromatographic column equipped with 20L D101 type resin; eluted with 20% ethanol 300L, 60% ethanol 120L successively, collected 60% ethanol eluted part, Concentrate under reduced pressure and dry to obtain light yellow crystalline powder, which is the Anemarrhena extract of the present invention, with a total weight of 0.14kg and a yield of 1.4% by crude drug weight.

Embodiment 2

[0106] The preparation of embodiment 2 Anemarrhena extract

[0107] Cut the medicinal material Anemarrhena into thin slices, take 10kg, heat extract with 50% ethanol 50L successively at 90-100°C for 3 times, each extraction time is 90 minutes, combine the extracts from 3 times, concentrate to 20L, filter, and pass the filtrate into In a chromatographic column equipped with 25L of ZTC-1 resin, elute with 500L of distilled water, 250L of 20% ethanol, and 150L of 50% ethanol in sequence, and collect the eluted part of 50% ethanol; concentrate the 50% ethanol eluate to 8L under reduced pressure , into a chromatographic column equipped with 10kg polyamide, elute with distilled water, collect 30L of distilled water eluate, concentrate under reduced pressure, and spray dry to obtain a light yellow powder, which is the Anemarrhena extract of the present invention, weighing 0.17kg in total, The yield is 1.7% by crude drug weight.

Embodiment 3

[0108] The preparation of embodiment 3 powder injections

[0109] Take 30g of Anemarrhena extract, add 30g of dextran, add 500ml of water for injection, stir to dissolve; add water for injection to 2000ml, add 3.0g of activated carbon for needles, stir for 30 minutes; decarbonize and filter; use 0.22μm microporous Membrane filtration; filling into sterile vials, 2ml per bottle, half stoppered; freeze-dried, then stoppered and capped.

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Abstract

The invention discloses an injection of anemarrhena extractive, which includes the various dosage types of powder injection, small injection, glucose fluid infusion and sodium chloride fluid infusion, wherein the main active constituent of anemarrhena extract includes anemarrhena saponin B-II, anemarrhena saponin E1, anemarrhena saponin B by the weight ratio of 78-92 : 2-12 : 0-6.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and is an injection form of anemarrhena extract, including powder injection, small injection, glucose infusion or sodium chloride infusion, and also relates to its new application for treating ischemic cerebrovascular diseases. Background technique: [0002] Zhimu is the rhizome of Anemarrhena asphodeloides Bunge, a plant of the Liliaceae family. It has the effects of nourishing yin and reducing fire, moisturizing dryness and smoothing intestines. [0003] The chemical constituents of Anemarrhena are mainly saponins and flavonoids. The timosaponins have significant preventive and treatment effects on senile dementia (invention patent application publication, publication number CN 1301166, application number 99806158.1; invention patent application publication publication number, publication number CN 1212966, application number 97119680.X), protect myocardial I / R injury (Journal of Capital Me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61P9/10
Inventor 陈万生钟延强娄子洋原源陶朝阳丁毅孙连娜殷学平
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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