Anti-cancer medicine composition containing antineoplastic antibiotics

Abstract

An anticancer pharmaceutical composition composed of pharmaceutic adjuvant and enwrapped in anti-tumor drug is provided. Wherein the anti-tumor drug is tumor resistant antibiotic, the pharmaceutic adjuvant is mainly biological compatible, degradable and absorbable macromolecule polymer. The anticancer drug can be sustained released to local tumor region in the degradation and absorption process, as a result, it can both decrease whole body toxic reaction considerably and maintain tumor local effective drug level.

Description

(1) Technical field

[0001] The invention relates to an anticancer pharmaceutical composition, which belongs to the technical field of medicines. (2) Background technology

[0002] The treatment of cancer mainly includes surgery, radiotherapy and chemotherapy. Among the various chemotherapeutics used, anti-tumor antibiotics have obvious effects and have been widely used in a variety of malignant tumors. However, the blood vessels, connective tissue, matrix proteins, fibronectin, and collagen in the tumor stroma not only provide scaffolds and essential nutrients for the growth of tumor cells, but also affect the chemotherapeutic drugs around the tumor and tumor tissues. Internal penetration and diffusion (see Netti et al. "The effect of extracellular matrix conditions on drug delivery in solid tumors", Cancer Research, Issue 60, pages 2497-503 (2000) (Netti PA, Cancer Res. 2000, 60 (9): 2497-503). Due to the excessive swelling and hyperplasia of solid tumors, the interstitial press...