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Amidine derivatives for treating amyloidosis

A technology of amyloid and amidine compounds, applied in the direction of drug combinations, organic active ingredients, non-central analgesics, etc., can solve problems that cannot be prevented or treated

Inactive Publication Date: 2005-08-24
NEUROCHEM INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are symptomatic treatments for Alzheimer's disease, there is currently no way to prevent or treat the disease

Method used

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  • Amidine derivatives for treating amyloidosis
  • Amidine derivatives for treating amyloidosis
  • Amidine derivatives for treating amyloidosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0304] 本发明的脒类化合物的合成已在美国专利5,428,051、4,963,589、5,202,320、5,935,982、5,521,189、5,686,456、5,627,184、5,622,955、5,606,058、5,668,167、5,667,975、6,025,398、6,214,883、5,817,687、5,792,782、5,939,440、6,017,941、5,972,969、6,046,226、 6,294,565(B1)、6,156,779、6,326,395、6,008,247、6,127,554、6,172,104、4,940,723、5,206,236、5,843,980、4,933,347、5,668,166、5,817,686、5,723,495、4,619,942、5,792,782、5,639,755、5,643,935、5,602,172、5,594,138和5,578,631中描述。 Many compounds are also commercially available from Sigma-Aldrich Co. (Milwaukee, USA). These compounds can also be synthesized according to methods known in the art.

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Abstract

The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula (X), such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited.

Description

[0001] related application [0002] This application requests serial number 60 / 316,761 (Atty. Docket No. NBI-105-1) filed August 31, 2001, and serial number 60 / 387,001 (Atty. Docket No. .NBI-105-2), which are hereby incorporated by reference. Background of the invention [0003] Amyloidosis refers to a pathological condition characterized by the appearance of amyloid fibrils. Amyloid is a genetic term referring to a group of distinct but specific protein deposits (intracellular or extracellular) that occur in many different diseases. Although their appearance varies, all amyloid deposits share a common morphological feature, staining with special stains (eg, Congo red) and having a distinctive red-green birefringent appearance in polarized light. They share common ultramicroscopic structural properties, X-ray diffraction and infrared spectroscopy. [0004] Amyloid-related disease can be confined to one organ or spread across several organs. The former refers to "localized ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61K31/136A61K31/155A61K31/166A61K31/167A61K31/18A61K31/195A61K31/20A61K31/341A61K31/343A61K31/40A61K31/403A61K31/404A61K31/4164A61K31/4178A61K31/4184A61K31/42A61K31/421A61K31/443A61K31/4439A61K31/505A61P3/10A61P9/00A61P21/00A61P25/28A61P29/00A61P43/00C07C257/18
CPCC07C257/18A61K31/341A61K31/4164A61K31/343A61K31/4184A61K31/155Y02P20/582A61P21/00A61P25/28A61P29/00A61P3/10A61P43/00A61P9/00
Inventor R·J·查利福尔孔宪起吴新福吕文硕
Owner NEUROCHEM INT