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Blends of different acyl gellan gums and starch

A technology of high-acyl gellan gum and low-acyl gellan gum, which can be applied in capsule delivery, drug delivery, food science, etc., and can solve the problems of inability to reduce structural and/or functional properties

Active Publication Date: 2005-09-07
CORN PROD DEV INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these approaches generally fail because the resulting products have different structural and / or functional properties that cannot be reduced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Example 1 - Preparation of Mixture

[0098] a. Premix 1.5g Kelcogel LT100, 1g Kelcogel F, 1g Aerosil 200 and 30g Starch A to obtain a powder mixture. This powder mixture was added to a beaker containing 18 g of glycerin dissolved in 48.5 g of distilled water. Blend the whole mixture to form a thick paste. The paste is then cooked with stirring at about 90-100°C using a steam bath until the solution becomes smooth and nearly transparent. The final viscosity is 30,000-50,000 centipoise.

[0099] b. Example 1a was repeated, but without Aerosil and the amount of water used was 49.5. The final viscosity and wet film strength are slightly lower compared to 1a.

[0100] c. Repeat Example 1a, but use Starch E instead of Starch A. c. The final viscosity was 70,000 cPs. Wet film strength is slightly higher than 1a.

[0101] d. Repeat Example 1a, but with 13 g of glycerol and 53.5 g of distilled water. The resulting viscosity is similar to 1a, and the dry film has a modulu...

Embodiment 2

[0110] Embodiment 2-preparation of film

[0111] The final solution from Example 1 is rapidly degassed while maintaining at this temperature, and the film is cast onto a glass or metal substrate covered with a thin layer of vegetable oil or other mold release agent using a film drawer with a gap of 0.6-1.4 mm .

[0112] Each wet film was sampled directly after cooling the film to room temperature of about 22.5°C. The dried film was sampled after drying at 22.5°C and 50% RH for about 24 hours.

Embodiment 3

[0113] Example 3 - Mechanical Testing

[0114] Film samples were cut to 20 mm wide and 55 mm long. These films gave an initial film length of 20 mm after clamping on a Texture Analyzer TA-XT2. These films were then stretched at a constant speed of 2 mm / min until breaking. Stress was determined using a 5kg Texture Analyzer transducer. Stress-strain curves are recorded automatically.

[0115] Calculate the modulus as the maximum strength divided by the elongation at break. Membrane strength was calculated by integrating the area under the stress-strain curve.

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PUM

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Abstract

The present invention relates to a method of producing a film forming blend of different acyl gellan gums with starch having similar textural and functional properties compared to gelatin. Films prepared using such blends have a high modulus and excellent strength and elongation. The present invention also relates to soft capsules prepared using such blends or films, which have good sealability.

Description

Background of the invention [0001] The present invention relates to a process for the preparation of mixtures of different acyl gellan gums with starch and plasticizers, said mixtures having similar structural and functional properties to gelatin. The present invention also relates to methods of using said mixtures for the preparation of films and soft capsules and methods for the preparation of such films and capsules. [0002] Gelatin is used in a variety of pharmaceutical applications, including soft and hard gelatin capsule shells, and in various food applications. Soft capsules are used to encapsulate solutions and dispersions, such as solutions and dispersions of nutritional and pharmaceutical actives in liquid carriers, and have many advantages over other dosage forms, such as easy-to-swallow, easy-to-transport, and basically tasteless dosage forms. Precise delivery of unit doses. [0003] However, gelatin has many drawbacks, including cost and continuity of security ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/00A23L29/20A61J3/07A61K9/48C08K5/00C08L3/00C08L5/00
CPCA61K9/4816A23L29/20
Inventor A·钱特拉努库尔C·肖Z·李S·查克拉巴蒂M·K·奥科尼夫斯卡
Owner CORN PROD DEV INC
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