Chinese medicinal in situ forming eye gel
An ophthalmic and gel technology, which is applied in the field of ophthalmic instant gel preparations of traditional Chinese medicine and ophthalmic instant gel preparations, to achieve the effects of good sustained release characteristics, good fluidity, and high transparency
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Embodiment 1
[0092] Prescription: bear bile powder 25g gellan gum 30g
[0093] Preparation method: Take bear bile powder, add 500ml of water for injection, heat to boil to dissolve, let cool, add ethanol to make the alcohol content reach 75%, let it stand for 24 hours, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, and set aside ; Take 4000ml of water for injection, add gellan gum, stir evenly, place in a boiling water bath, stir until clarified, add 60g of boric acid, 3g of borax, 4g of ethylparaben, stir until clarified, heat to 70°C, and pass through a microporous filter Membrane (0.8μm), add the above-mentioned bear bile aqueous solution under stirring, pass through a microporous membrane (0.45μm), add water for injection to 5kg, autoclave at 120°C for 20 minutes, let cool, and aseptically dispense to obtain.
Embodiment 2
[0095] Prescription: bear bile powder 25g natural borneol 4g gellan gum 20g
[0096] Preparation method: Take bear bile powder, add 500ml of water for injection, heat to boil to dissolve, let it cool, add ethanol to make the alcohol content reach 70%, let it stand for 24 hours, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, and set aside ; Take 4000ml of water for injection, add gellan gum, stir evenly, place in a boiling water bath, stir until clear, add triethanolamine and 1g of benzalkonium chloride, stir until clear, heat to 70°C, slowly add natural Borneol, mix well, pass through a microporous membrane (0.8 μm), add the above bear bile aqueous solution under stirring, heat to 70°C, pass through a microporous membrane (0.45 μm), add water for injection to 5 kg, pass through a microporous membrane (0.22μm), aseptically dispensed, ready to use.
Embodiment 3
[0098] Prescription: pearl liquid 20ml, borneol 1g, gellan gum 6g
[0099] Preparation method: Take pearl powder, add 4 times the amount of water for injection, heat to boiling, keep warm for 24 hours, pour out the supernatant, filter to get pearl liquid (containing no less than 1mg / ml of total protein); take manna Add alcohol to 900ml of water for injection and stir to dissolve, heat to 95-100°C, add 6g of gellan gum, stir to dissolve, let cool to room temperature; take 1g of borneol, 0.8g of ethyl paraben, add 5ml of ethanol to dissolve, Add 10g of Tween-80, add to the above solution under stirring, then add 20ml of pearl liquid, add water for injection to 1000ml, pass through a microporous membrane (0.22μm), and aseptically dispense to obtain.
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