Chinese medicinal in situ forming eye gel

An ophthalmic and gel technology, which is applied in the field of ophthalmic instant gel preparations of traditional Chinese medicine and ophthalmic instant gel preparations, to achieve the effects of good sustained release characteristics, good fluidity, and high transparency

Inactive Publication Date: 2009-10-28
代龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] How to apply gellan gum to ophthalmic preparations is the focus of current ophthalmic drug research, especially in the field of traditional Chine

Method used

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  • Chinese medicinal in situ forming eye gel
  • Chinese medicinal in situ forming eye gel
  • Chinese medicinal in situ forming eye gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Prescription: bear bile powder 25g gellan gum 30g

[0093] Preparation method: Take bear bile powder, add 500ml of water for injection, heat to boil to dissolve, let cool, add ethanol to make the alcohol content reach 75%, let it stand for 24 hours, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, and set aside ; Take 4000ml of water for injection, add gellan gum, stir evenly, place in a boiling water bath, stir until clarified, add 60g of boric acid, 3g of borax, 4g of ethylparaben, stir until clarified, heat to 70°C, and pass through a microporous filter Membrane (0.8μm), add the above-mentioned bear bile aqueous solution under stirring, pass through a microporous membrane (0.45μm), add water for injection to 5kg, autoclave at 120°C for 20 minutes, let cool, and aseptically dispense to obtain.

Embodiment 2

[0095] Prescription: bear bile powder 25g natural borneol 4g gellan gum 20g

[0096] Preparation method: Take bear bile powder, add 500ml of water for injection, heat to boil to dissolve, let it cool, add ethanol to make the alcohol content reach 70%, let it stand for 24 hours, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, and set aside ; Take 4000ml of water for injection, add gellan gum, stir evenly, place in a boiling water bath, stir until clear, add triethanolamine and 1g of benzalkonium chloride, stir until clear, heat to 70°C, slowly add natural Borneol, mix well, pass through a microporous membrane (0.8 μm), add the above bear bile aqueous solution under stirring, heat to 70°C, pass through a microporous membrane (0.45 μm), add water for injection to 5 kg, pass through a microporous membrane (0.22μm), aseptically dispensed, ready to use.

Embodiment 3

[0098] Prescription: pearl liquid 20ml, borneol 1g, gellan gum 6g

[0099] Preparation method: Take pearl powder, add 4 times the amount of water for injection, heat to boiling, keep warm for 24 hours, pour out the supernatant, filter to get pearl liquid (containing no less than 1mg / ml of total protein); take manna Add alcohol to 900ml of water for injection and stir to dissolve, heat to 95-100°C, add 6g of gellan gum, stir to dissolve, let cool to room temperature; take 1g of borneol, 0.8g of ethyl paraben, add 5ml of ethanol to dissolve, Add 10g of Tween-80, add to the above solution under stirring, then add 20ml of pearl liquid, add water for injection to 1000ml, pass through a microporous membrane (0.22μm), and aseptically dispense to obtain.

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Abstract

The invention discloses a Chinese medicinal in situ forming eye gel preparation, and belongs to the field of Chinese medicament. Active ingredients of the preparation come from Chinese medicinal bulk medicaments, and the gel base materials of the preparation mainly comprise Gellan gum which is 0.4 to 0.7 percent of the weight of a finished product. The technical proposal overcomes the defects of low bioavailability, inconvenient use, short detention time and the like of the prior Chinese medicinal eye preparations, and achieves the effects of reducing applied dosage, prolonging the detention time in the eyes, convenient use, accurate applied dosage and the like.

Description

technical field [0001] The invention relates to an instant ophthalmic gel preparation of traditional Chinese medicine, in particular to an instant ophthalmic gel preparation with gellan gum as the main gel base material, belonging to the field of traditional Chinese medicine. Background technique [0002] Among the current ophthalmic preparations, eye drops, as a traditional dosage form, have the advantages of convenient use, good compliance, and low price. big impact. Studies have shown that the volume of a drop of eye drops is basically between 25 and 50ul. If you do not blink, the volume of the liquid in the eye is only 30ul, and if you blink, it will be reduced to 10ul. Therefore, most of the externally used drugs do not enter the eye tissue. Instead, it drains through the nasolacrimal system and eyelid crevices. According to tear dynamics, the residence time of ophthalmic solutions on the ocular surface is very short, and the amount of drug absorbed is usually only a ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/36A61K47/38A61K47/40A61K35/413A61K35/56A61K36/28A61K36/48A61K36/56A61K36/66A61K36/78A61K36/906A61P27/02A61K31/045A61K35/618
Inventor 朴美善王广录
Owner 代龙
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