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Water soluble bilirubin and its synthesis process and use

A synthesis method and bilirubin technology, which can be applied in the directions of effective components of heterocyclic compounds, drug combinations, cardiovascular system diseases, etc., can solve the problems of lack of physiological efficacy, and achieve the effects of good product stability and simple method.

Inactive Publication Date: 2006-01-18
张恒洲
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that free bilirubin is insoluble in water and has no physiological efficacy

Method used

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  • Water soluble bilirubin and its synthesis process and use
  • Water soluble bilirubin and its synthesis process and use
  • Water soluble bilirubin and its synthesis process and use

Examples

Experimental program
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Effect test

example 1

[0031] Get 10% blood plasma (or lyophilized powder) of glucuronic acid or xylitol or glycine or taurine or sodium hydroxide or sodium carbonate or zinc sulfate or potassium hydroxide or potassium carbonate solubilized potassium or sodium carbonate or 0.1-10% potassium carbonate solution 10-500ml, then add catalytic enzyme (bilirubin oxidase or bilirubin synthase or bilirubin esterase or bilirubin acetylase or bilirubin converting enzyme) 0.1-5.0 grams. Then add 0.1g of bilirubin, react for 10-60 minutes, refine, purify, concentrate, dry at room temperature or high temperature or vacuum to a powder form with a moisture content of the solid ≤ 2.0%, and pulverize to obtain usable water-soluble bilirubin.

example 2

[0033] Take 10kg of fresh animal blood, add 20 to 500 times of water to dilute, go through an ultrafilter for 2 to 20 times of ultrafiltration, concentrate, dry, and pulverize to obtain water-soluble bilirubin. The ultrafiltration membrane used in the above ultrafilter has a molecular weight cut off of 100 to 200,000.

example 3

[0035] Take 1-20g of bilirubin dimethyl ester, add 20-500ml of methanol, and then add glucuronic acid or xylitol or glycine or taurine or sodium hydroxide or sodium carbonate or zinc sulfate with a concentration of 0.1%-10% Or potassium hydroxide or potassium carbonate solution 10 ~ 500ml, after refluxing for 10 ~ 60 minutes. After refinement, purification, concentration, normal temperature or high temperature or vacuum drying to a powder form with a moisture content of the solid matter ≤ 2.0%, and pulverization, the usable water-soluble bilirubin can be obtained.

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Abstract

The present invention relates to new compound, and is especially one kind of water soluble cholerythrin and its synthesis process and use. Cholerythrin is made to combine with matter with hydrophilic group to form one new matter comprising cholerythrin and two hydrophilic groups, and the new matter may be used in preparing medicine for preventing and treating cardiac, cerebral and nephric vascular diseases and Parkinson's disease.

Description

technical field [0001] The present invention relates to a new compound, its preparation method and application of the compound. Background technique [0002] Bilirubin is mainly derived from the catabolism of hemoglobin. The traditional concept is that bilirubin is a harmful substance in the human body, and the lower the concentration, the better. is an important compound. Normal blood contains 0.1-1.0mg / ml% bilirubin. Professional literature generally divides bilirubin into two types: conjugated bilirubin and free bilirubin (also known as direct bilirubin and indirect bilirubin). Studies have found that free bilirubin is insoluble in water and has no physiological efficacy. Further research found that the so-called indirect bilirubin is not free bilirubin, but a derivative of bilirubin. The latest research has found that bilirubin derivatives are a very important physiological antioxidant, which can prevent the oxidation of low-density lipoproteins. Therefore, high seru...

Claims

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Application Information

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IPC IPC(8): C07D207/337A61K31/40A61P25/16A61P9/00
Inventor 张恒洲
Owner 张恒洲
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