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Prepn process of 2,5-dihalogeno benzoic acid

A technology of dihalogenated benzoic acid and dihalogenated trifluorotoluene, which is applied in the field of preparation of dihalogenated benzoic acid, can solve the problems of complex process and high production cost, and achieve the effects of simple process and low cost

Inactive Publication Date: 2006-03-01
LYNCHEM
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Dihalogenated benzoic acid is a kind of useful drug intermediate, and existing synthetic method is to utilize composite catalyst mostly to prepare dihalogenated benzoic acid by oxidation of dihalogenated toluene in air, because of its complicated process, so production cost is relatively high. high

Method used

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  • Prepn process of 2,5-dihalogeno benzoic acid
  • Prepn process of 2,5-dihalogeno benzoic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0014] Synthesis of 2-chloro-5-bromobenzoic acid

[0015] Add 41.5 g of 2-chloro-5-bromobenzotrifluoride to a four-necked flask equipped with a stirrer, a thermometer, a dropping funnel, and a reflux condenser, containing 20% ​​SO 3 63g of oleum, heated to 58-65°C, continued to react at this temperature for 12 hours, cooled to below 50°C, added 200g of crushed ice, and filtered to obtain 35-40g of crude product. Recrystallized from toluene to obtain 28.5 g of the product with a purity of 99% and a yield of 75.6%.

[0016] m.p.: 154~156℃;

[0017] MS (m / z, M + ): 238;

[0018] IR (KBr, cm -1 ): 3300-2500, 3089, 2630, 2530, 1870, 1813, 1694, 1580, 1462, 845, 820, 781, 731, 657, 596.

[0019] Those skilled in the art can understand that the reaction temperature in the method of the present invention can be between 50-100°C. And the specific reaction time can be determined according to the actual product to be obtained. And can be selected according to the property of produ...

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Abstract

The present invention discloses the preparation process of 2, 5-dihalogeno benzoic acid with the general expression as shown. The preparation process includes hydrolysis of 2, 5-dihalogeno trifluoro toluene under acid condition to obtain 2, 5-dihalogeno benzoic acid. The preparation process can realize the synthesis of the target compound in low cost and high yield.

Description

technical field [0001] The present invention relates to the preparation method of dihalogenated benzoic acid, particularly relate to the method for preparing dihalogenated benzoic acid by hydrolysis reaction. Background technique [0002] Dihalogenated benzoic acid is a kind of useful drug intermediate, and existing synthetic method is to utilize composite catalyst mostly to prepare dihalogenated benzoic acid by oxidation of dihalogenated toluene in air, because of its complicated process, so production cost is relatively high. high. Therefore, it is necessary to provide a kind of preparation method of dihalobenzoic acid with simple technique and low cost. Contents of the invention [0003] The purpose of the present invention is to overcome the deficiencies in the prior art and provide a method for preparing 2,5-dihalobenzoic acid, which has simple process and low cost. [0004] In order to achieve the above object, the present invention provides a method for preparing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C63/10C07C51/093
Inventor 陈荣业卜勇刚
Owner LYNCHEM
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